Pathological and immunohistochemical features of 45 cases of feline meningioma

Meningioma is the most common primary brain tumor in cats, although there are few reports about their pathological features. To investigate the histopathological subtypes and immunohistochemical features including expression of cytokeratin and cell adhesion molecules, 45 cases of feline meningioma w...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2021, Vol.83(8), pp.1219-1224
Main Authors: SAITO, Ryo, CHAMBERS, James K, KISHIMOTO, Takuya E., UCHIDA, Kazuyuki
Format: Article
Language:English
Subjects:
Brain tumors
cat
Cell adhesion molecules
Cerebellum
Cerebrum
Cholesterol
Cytokeratin
E-cadherin
Immunohistochemistry
Meningioma
Mineralization
N-Cadherin
Pathology
proliferation index
Spinal cord
Statistical analysis
Tumor cells
Vimentin
β-Catenin
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Summary:Meningioma is the most common primary brain tumor in cats, although there are few reports about their pathological features. To investigate the histopathological subtypes and immunohistochemical features including expression of cytokeratin and cell adhesion molecules, 45 cases of feline meningioma were examined. The mean age was 12.5 years (range 6–21 years). No statistically significant sex predilection was observed. Regarding the anatomical location of meningioma, tumors mostly developed in the cerebrum, followed by spinal cord and cerebellum, and multiple meningioma was observed in one cat. Microscopically, linear or focal mineralization was observed in 40 cases and cholesterol cleft was observed in 14 cases. Based on histopathological subtypes, there were 15 fibrous, 22 transitional, 2 meningothelial, 5 atypical, and 1 anaplastic meningiomas. These subtypes are classified into grade 1 (39 cases), grade 2 (5 cases), and grade 3 (1 case). There was no significant difference in the Ki-67 index among histological subtypes or grades. Immunohistochemically, the tumor cells were positive for cytokeratin in 5 cases (12.8%), vimentin in 17 cases (43.6%), E-cadherin in 36 cases (92.3%), β-catenin in 21 cases (53.8%), and N-cadherin in 1 case (2.6%), demonstrating the utility of E-cadherin-immunohistochemistry for the diagnosis of feline meningiomas.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.21-0258