Characterization and expression of DNA sequences encoding the growth hormone gene in African Pygmy Mouse (Mus minutoides)

We determined the nucleotide sequence of the growth hormone (Gh) gene in Mus minutoides, one of the smallest mammals, where was predicted to be distinct in the functional regions between M. minutoides and Mus musculus. To investigate the evolutionary characteristics of Gh in M. minutoides, we constr...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2021, Vol.83(8), pp.1244-1247
Main Authors: MATSUYA, Sumito, IMAI, Hiroyuki, KISO, Yasuo, KUSAKABE, Ken Takeshi, KANO, Kiyoshi
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
body size
evolution
Evolution, Molecular
growth hormone
Growth Hormone - genetics
Growth hormones
Laboratory Animal Science
Mice - genetics
mouse
Mus minutoides
Nucleotide sequence
Phylogeny
Regulatory sequences
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Summary:We determined the nucleotide sequence of the growth hormone (Gh) gene in Mus minutoides, one of the smallest mammals, where was predicted to be distinct in the functional regions between M. minutoides and Mus musculus. To investigate the evolutionary characteristics of Gh in M. minutoides, we constructed a phylogenetic tree based on the putative amino acid sequences of Gh, suggesting that the Gh of M. minutoides diverged earlier than M. musculus. Furthermore, the Gh gene expressed higher in M. minutoides than in M. musculus. Our results suggest that the specific feature of the Gh in M. minutoides is in rather the regulatory mechanism than the sequence.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.21-0231