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Predictors of smell recovery in a nationwide prospective cohort of patients with COVID-19
To determine which factors (demographic, symptoms, comorbidities, and treatments) are associated with recovery of smell in patients with COVID-19 associated olfactory loss. Prospective, longitudinal questionnaires. National survey. A longitudinal web-based nationwide survey of adults with COVID-19 a...
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| Published in: | American journal of otolaryngology 2022-01, Vol.43 (1), p.103239-103239, Article 103239 |
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| container_end_page | 103239 |
| container_issue | 1 |
| container_start_page | 103239 |
| container_title | American journal of otolaryngology |
| container_volume | 43 |
| creator | Coelho, Daniel H. Reiter, Evan R. Budd, Serenity G. Shin, Yongyun Kons, Zachary A. Costanzo, Richard M. |
| description | To determine which factors (demographic, symptoms, comorbidities, and treatments) are associated with recovery of smell in patients with COVID-19 associated olfactory loss.
Prospective, longitudinal questionnaires.
National survey.
A longitudinal web-based nationwide survey of adults with COVID-19 associated smell and taste loss was launched April 10, 2020. After completing an initial entry survey, participants received detailed follow-up questionnaires 14 days, and 1, 3 and 6 months later.
As of June 25, 2021, 798 participants met study inclusion criteria and completed 6-month questionnaires. Of demographic characteristics only age |
| doi_str_mv | 10.1016/j.amjoto.2021.103239 |
| format | article |
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Prospective, longitudinal questionnaires.
National survey.
A longitudinal web-based nationwide survey of adults with COVID-19 associated smell and taste loss was launched April 10, 2020. After completing an initial entry survey, participants received detailed follow-up questionnaires 14 days, and 1, 3 and 6 months later.
As of June 25, 2021, 798 participants met study inclusion criteria and completed 6-month questionnaires. Of demographic characteristics only age <40 years was positively associated with smell recovery (p < .003). Of symptoms, difficulty breathing was negatively associated with smell recovery (p < .004), and nasal congestion positively associated with smell recovery (p < .03). Of pre-existing comorbidities only previous head injury (p < .017) was negatively associated with smell recovery. None of the queried medications used to treat COVID were associated with better rates of smell recovery.
Age <40 and presence of nasal congestion at time of COVID-19 infection were predictive of improved rates of smell recovery, while difficulty breathing at time of COVID-19 infection, and prior head trauma predicted worsened rates of recovery. Further study will be required to identify potential mechanisms for the other observed associations. Such information can be used by clinicians to counsel patients suffering COVID-19 associated smell loss as to prognosis for recovery.]]></description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2021.103239</identifier><identifier>PMID: 34547716</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age ; Blood groups ; Body mass index ; Congestion ; Coronavirus ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; Demographics ; Epidemiology ; Female ; Head injuries ; Humans ; Infections ; Longitudinal Studies ; Male ; Middle Aged ; Olfaction ; Olfaction Disorders - physiopathology ; Olfaction Disorders - virology ; Pandemics ; Patients ; Polls & surveys ; Predictive Value of Tests ; Prospective Studies ; Questionnaires ; Recovery ; Recovery (Medical) ; Recovery of Function ; Risk factors ; SARS-CoV-2 ; Smell ; Surveys and Questionnaires ; Taste ; Trauma</subject><ispartof>American journal of otolaryngology, 2022-01, Vol.43 (1), p.103239-103239, Article 103239</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><rights>2021. Elsevier Inc.</rights><rights>2021 Elsevier Inc. All rights reserved. 2021 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-9908e2e9825cecab52410fed5f54ca31cc96e5cd501374181cacf429b99b41093</citedby><cites>FETCH-LOGICAL-c491t-9908e2e9825cecab52410fed5f54ca31cc96e5cd501374181cacf429b99b41093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34547716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coelho, Daniel H.</creatorcontrib><creatorcontrib>Reiter, Evan R.</creatorcontrib><creatorcontrib>Budd, Serenity G.</creatorcontrib><creatorcontrib>Shin, Yongyun</creatorcontrib><creatorcontrib>Kons, Zachary A.</creatorcontrib><creatorcontrib>Costanzo, Richard M.</creatorcontrib><title>Predictors of smell recovery in a nationwide prospective cohort of patients with COVID-19</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description><![CDATA[To determine which factors (demographic, symptoms, comorbidities, and treatments) are associated with recovery of smell in patients with COVID-19 associated olfactory loss.
Prospective, longitudinal questionnaires.
National survey.
A longitudinal web-based nationwide survey of adults with COVID-19 associated smell and taste loss was launched April 10, 2020. After completing an initial entry survey, participants received detailed follow-up questionnaires 14 days, and 1, 3 and 6 months later.
As of June 25, 2021, 798 participants met study inclusion criteria and completed 6-month questionnaires. Of demographic characteristics only age <40 years was positively associated with smell recovery (p < .003). Of symptoms, difficulty breathing was negatively associated with smell recovery (p < .004), and nasal congestion positively associated with smell recovery (p < .03). Of pre-existing comorbidities only previous head injury (p < .017) was negatively associated with smell recovery. None of the queried medications used to treat COVID were associated with better rates of smell recovery.
Age <40 and presence of nasal congestion at time of COVID-19 infection were predictive of improved rates of smell recovery, while difficulty breathing at time of COVID-19 infection, and prior head trauma predicted worsened rates of recovery. Further study will be required to identify potential mechanisms for the other observed associations. Such information can be used by clinicians to counsel patients suffering COVID-19 associated smell loss as to prognosis for recovery.]]></description><subject>Adult</subject><subject>Age</subject><subject>Blood groups</subject><subject>Body mass index</subject><subject>Congestion</subject><subject>Coronavirus</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>Demographics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Head injuries</subject><subject>Humans</subject><subject>Infections</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Olfaction</subject><subject>Olfaction Disorders - physiopathology</subject><subject>Olfaction Disorders - virology</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Polls & surveys</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Questionnaires</subject><subject>Recovery</subject><subject>Recovery (Medical)</subject><subject>Recovery of Function</subject><subject>Risk factors</subject><subject>SARS-CoV-2</subject><subject>Smell</subject><subject>Surveys and Questionnaires</subject><subject>Taste</subject><subject>Trauma</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUtvEzEUhS0EomngHyBkiQ2bCX7OjDdIKFCoVKksAMHKcu7cIR5lxoPtpOq_x1FKeSxYWbLPub7nfIQ842zFGa9fDSs3DiGHlWCClysppHlAFlxLUbW8_fqQLBg3dcUaZs7IeUoDY0wqqR-TM6m0ahpeL8i3jxE7DznERENP04i7HY0I4YDxlvqJOjq57MN04zukcwxpRsj-gBTCNsR8NM1FgFNO9MbnLV1ff7l8W3HzhDzq3S7h07tzST5fvPu0_lBdXb-_XL-5qkAZnitjWIsCTSs0ILiNFoqzHjvdawVOcgBTo4ZOMy4bxVsODnolzMaYTVEauSSvT3Pn_WbEDsom0e3sHP3o4q0Nztu_Xya_td_DwbaqlFFaW5KXdwNi-LHHlO3oE5Qe3IRhn6zQjZaNlDUv0hf_SIewj1OJZ0XNtJA1q2VRqZMKSl0pYn-_DGf2yM4O9sTOHtnZE7tie_5nkHvTL1i_k2Kp8-Ax2gSleCgAC7Fsu-D__8NPZeas5A</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Coelho, Daniel H.</creator><creator>Reiter, Evan R.</creator><creator>Budd, Serenity G.</creator><creator>Shin, Yongyun</creator><creator>Kons, Zachary A.</creator><creator>Costanzo, Richard M.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220101</creationdate><title>Predictors of smell recovery in a nationwide prospective cohort of patients with COVID-19</title><author>Coelho, Daniel H. ; Reiter, Evan R. ; Budd, Serenity G. ; Shin, Yongyun ; Kons, Zachary A. ; Costanzo, Richard M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-9908e2e9825cecab52410fed5f54ca31cc96e5cd501374181cacf429b99b41093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Age</topic><topic>Blood groups</topic><topic>Body mass index</topic><topic>Congestion</topic><topic>Coronavirus</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - complications</topic><topic>Demographics</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Head injuries</topic><topic>Humans</topic><topic>Infections</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Olfaction</topic><topic>Olfaction Disorders - physiopathology</topic><topic>Olfaction Disorders - virology</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Polls & surveys</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Questionnaires</topic><topic>Recovery</topic><topic>Recovery (Medical)</topic><topic>Recovery of Function</topic><topic>Risk factors</topic><topic>SARS-CoV-2</topic><topic>Smell</topic><topic>Surveys and Questionnaires</topic><topic>Taste</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coelho, Daniel H.</creatorcontrib><creatorcontrib>Reiter, Evan R.</creatorcontrib><creatorcontrib>Budd, Serenity G.</creatorcontrib><creatorcontrib>Shin, Yongyun</creatorcontrib><creatorcontrib>Kons, Zachary A.</creatorcontrib><creatorcontrib>Costanzo, Richard M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coelho, Daniel H.</au><au>Reiter, Evan R.</au><au>Budd, Serenity G.</au><au>Shin, Yongyun</au><au>Kons, Zachary A.</au><au>Costanzo, Richard M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of smell recovery in a nationwide prospective cohort of patients with COVID-19</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>43</volume><issue>1</issue><spage>103239</spage><epage>103239</epage><pages>103239-103239</pages><artnum>103239</artnum><issn>0196-0709</issn><eissn>1532-818X</eissn><abstract><![CDATA[To determine which factors (demographic, symptoms, comorbidities, and treatments) are associated with recovery of smell in patients with COVID-19 associated olfactory loss.
Prospective, longitudinal questionnaires.
National survey.
A longitudinal web-based nationwide survey of adults with COVID-19 associated smell and taste loss was launched April 10, 2020. After completing an initial entry survey, participants received detailed follow-up questionnaires 14 days, and 1, 3 and 6 months later.
As of June 25, 2021, 798 participants met study inclusion criteria and completed 6-month questionnaires. Of demographic characteristics only age <40 years was positively associated with smell recovery (p < .003). Of symptoms, difficulty breathing was negatively associated with smell recovery (p < .004), and nasal congestion positively associated with smell recovery (p < .03). Of pre-existing comorbidities only previous head injury (p < .017) was negatively associated with smell recovery. None of the queried medications used to treat COVID were associated with better rates of smell recovery.
Age <40 and presence of nasal congestion at time of COVID-19 infection were predictive of improved rates of smell recovery, while difficulty breathing at time of COVID-19 infection, and prior head trauma predicted worsened rates of recovery. Further study will be required to identify potential mechanisms for the other observed associations. Such information can be used by clinicians to counsel patients suffering COVID-19 associated smell loss as to prognosis for recovery.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34547716</pmid><doi>10.1016/j.amjoto.2021.103239</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0196-0709 |
| ispartof | American journal of otolaryngology, 2022-01, Vol.43 (1), p.103239-103239, Article 103239 |
| issn | 0196-0709 1532-818X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8443532 |
| source | ScienceDirect Journals |
| subjects | Adult Age Blood groups Body mass index Congestion Coronavirus Coronaviruses COVID-19 COVID-19 - complications Demographics Epidemiology Female Head injuries Humans Infections Longitudinal Studies Male Middle Aged Olfaction Olfaction Disorders - physiopathology Olfaction Disorders - virology Pandemics Patients Polls & surveys Predictive Value of Tests Prospective Studies Questionnaires Recovery Recovery (Medical) Recovery of Function Risk factors SARS-CoV-2 Smell Surveys and Questionnaires Taste Trauma |
| title | Predictors of smell recovery in a nationwide prospective cohort of patients with COVID-19 |
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