Macrophage lineages in heart valve development and disease

Abstract Heterogeneous macrophage lineages are present in the aortic and mitral valves of the heart during development and disease. These populations include resident macrophages of embryonic origins and recruited monocyte-derived macrophages prevalent in disease. Soon after birth, macrophages from...

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Bibliographic Details
Published in:Cardiovascular research 2021-02, Vol.117 (3), p.663-673
Main Authors: Kim, Andrew J, Xu, Na, Yutzey, Katherine E
Format: Article
Language:English
Subjects:
Animals
Cardiovascular Agents - therapeutic use
Cell Lineage
Developmental Biology and Regeneration Focus
Gene Expression Regulation, Developmental
Heart Valve Diseases - drug therapy
Heart Valve Diseases - genetics
Heart Valve Diseases - metabolism
Heart Valve Diseases - pathology
Heart Valves - drug effects
Heart Valves - metabolism
Heart Valves - pathology
Humans
Macrophages - drug effects
Macrophages - metabolism
Macrophages - pathology
Molecular Targeted Therapy
Morphogenesis
Phenotype
Receptors, CCR2 - antagonists & inhibitors
Receptors, CCR2 - metabolism
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Summary:Abstract Heterogeneous macrophage lineages are present in the aortic and mitral valves of the heart during development and disease. These populations include resident macrophages of embryonic origins and recruited monocyte-derived macrophages prevalent in disease. Soon after birth, macrophages from haematopoietic lineages are recruited to the heart valves, and bone marrow transplantation studies in mice demonstrate that haematopoietic-derived macrophages continue to invest adult valves. During myxomatous heart valve disease, monocyte-derived macrophages are recruited to the heart valves and they contribute to valve degeneration in a mouse model of Marfan syndrome. Here, we review recent studies of macrophage lineages in heart valve development and disease with discussion of clinical significance and therapeutic applications.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvaa062