Line‐field confocal optical coherence tomography of xanthogranuloma: Correlation with vertical and horizontal histopathology

Line‐field confocal optical coherence tomography (LC‐OCT) is a new noninvasive technique for a real‐time, vertical, and horizontal imaging of the skin at cellular resolution. A 47‐year‐old female presented with a 6‐month history of an asymptomatic yellowish papule. LC‐OCT evaluation was able to show...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2021-09, Vol.48 (9), p.1208-1211
Main Authors: Lacarrubba, Francesco, Verzì, Anna Elisa, Puglisi, Davide Francesco, Broggi, Giuseppe, Caltabiano, Rosario, Micali, Giuseppe
Format: Article
Language:English
Subjects:
Case Report
Case Reports
Female
foamy histiocytes
Giant cells
Giant Cells - pathology
Granuloma - diagnosis
Granuloma - pathology
Histiocytes - pathology
Histiocytosis - diagnosis
Histiocytosis - pathology
Histiocytosis - surgery
Histological Techniques - methods
histopathology
Humans
line‐field confocal optical coherence tomography
Margins of Excision
Microscopy, Confocal - methods
Middle Aged
Skin - diagnostic imaging
Skin - pathology
Skin - ultrastructure
Skin Neoplasms - pathology
Skin Neoplasms - ultrastructure
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - ultrastructure
Tomography
Tomography, Optical Coherence - methods
Touton cells
xanthogranuloma
Xanthomatosis - diagnosis
Xanthomatosis - pathology
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Summary:Line‐field confocal optical coherence tomography (LC‐OCT) is a new noninvasive technique for a real‐time, vertical, and horizontal imaging of the skin at cellular resolution. A 47‐year‐old female presented with a 6‐month history of an asymptomatic yellowish papule. LC‐OCT evaluation was able to show the diagnostic microscopic features of xanthogranuloma and showed an excellent correlation with vertical and horizontal histopathological sections by revealing enlarged dermal papillae containing multiple, bright roundish giant cells, corresponding to foamy histiocytes, and giant cells characterized by a dark center surrounded by a highly hyper‐refractile peripheral ring, corresponding to Touton cells. LC‐OCT may represent a valid, noninvasive alternative to histopathological examination in clinically atypical cases of xanthogranuloma.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14067