Association of Low Molecular Weight Plasma Aminothiols with the Severity of Coronavirus Disease 2019

• Published in: Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.9221693-9221693
• Main Authors: Kryukov, Evgeny Vladimirovich, Ivanov, Alexander Vladimirovich, Karpov, Vladimir Olegovich, Vasil’evich Alexandrin, Valery, Dygai, Alexander Mikhaylovich, Kruglova, Maria Petrovna, Kostiuchenko, Gennady Ivanovich, Kazakov, Sergei Petrovich, Kubatiev, Aslan Amirkhanovich
• Format: Article
• Language: English
• Subjects: Acids; Advanced Oxidation Protein Products - blood; Aged; Amino Acids, Sulfur - blood; Biomarkers - blood; Chromatography; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - diagnosis; COVID-19 - pathology; Dipeptides - blood; Dipeptides - metabolism; Disease; Female; Gene expression; Glutathione - blood; Glutathione - metabolism; Homocysteine; Humans; Infections; Laboratories; Lung - diagnostic imaging; Lung - pathology; Male; Middle Aged; Molecular weight; Oxidation-Reduction; Oxidative stress; Plasma; Proteins; SARS-CoV-2 - isolation & purification; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Software
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2021/9221693

Objective. Aminothiols (glutathione (GSH), cysteinylglycine (CG)) may play an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), but the possible association of these indicators with the severity of COVID-19 has not yet been investigated. Methods. The total content (t) and reduced forms (r) of aminothiols were determined in patients with COVID-19 (n=59) on admission. Lung injury was characterized by computed tomography (CT) findings in accordance with the CT0-4 classification. Results. Low tGSH level was associated with the risk of severe COVID-19 (tGSH≤1.5 μM, mild vs. moderate/severe: risk ratio RR=3.09, p=0.007) and degree of lung damage (tGSH≤1.8 μM, CT