Performance of non-invasive fibrosis scores in non-alcoholic fatty liver disease with and without morbid obesity

Background Non-invasive scores, such as the non-alcoholic fatty liver disease (NAFLD) Fibrosis Score (NFS), are increasingly used for liver fibrosis assessment in patients with NAFLD. The aim of this study was to assess the applicability and reliability of non-invasive fibrosis scores in NAFLD patie...

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Bibliographic Details
Published in:International Journal of Obesity 2021-10, Vol.45 (10), p.2197-2204
Main Authors: Drolz, Andreas, Wolter, Stefan, Wehmeyer, Malte H., Piecha, Felix, Horvatits, Thomas, Schulze zur Wiesch, Julian, Lohse, Ansgar W., Mann, Oliver, Kluwe, Johannes
Format: Article
Language:English
Subjects:
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Adult
Area Under Curve
Biopsy
Body Mass Index
Body size
Complications and side effects
Development and progression
Epidemiology
Evaluation
Fatty liver
Female
Fibrosis
Fibrosis - classification
Fibrosis - diagnosis
Fibrosis - etiology
Gastrointestinal surgery
Health Promotion and Disease Prevention
Humans
Internal Medicine
Liver
Liver cirrhosis
Liver diseases
Male
Medical screening
Medicine
Medicine & Public Health
Metabolic Diseases
Methods
Middle Aged
Non-alcoholic Fatty Liver Disease - classification
Non-alcoholic Fatty Liver Disease - physiopathology
Obesity
Obesity, Morbid - complications
Patients
Prognosis
Public Health
Reliability analysis
Reproducibility of Results
Risk factors
ROC Curve
Severity of Illness Index
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Summary:Background Non-invasive scores, such as the non-alcoholic fatty liver disease (NAFLD) Fibrosis Score (NFS), are increasingly used for liver fibrosis assessment in patients with NAFLD. The aim of this study was to assess the applicability and reliability of non-invasive fibrosis scores in NAFLD patients with and without morbid obesity. Methods Three hundred sixty-eight patients with biopsy-proven NAFLD identified between January 2012 and December 2015 were studied; 225 with morbid obesity (biopsy obtained during bariatric surgery) and 143 patients without (termed as “conventional”). Results Median age was 47 years, 57% were female. Median body mass index (BMI) was 42.9 kg/m 2 with significant differences between our conventional and morbidly obese patients (BMI 29.0 vs. 50.8 kg/m 2 , p  
ISSN:0307-0565
1476-5497
DOI:10.1038/s41366-021-00881-8