Impact of the COVID-19 pandemic on the incidence of multidrug-resistant bacterial infections in an acute care hospital in Brazil

• Published in: American journal of infection control 2022-01, Vol.50 (1), p.32-38
• Main Authors: Polly, Matheus, de Almeida, Bianca L., Lennon, Robert P., Cortês, Marina Farrel, Costa, Silvia F., Guimarães, Thais
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Bacterial Infections - epidemiology; Brazil - epidemiology; Carbapenem-resistant Acinetobacter baumannii infection; COVID-19; Cross Infection - drug therapy; Cross Infection - epidemiology; Drug Resistance, Multiple, Bacterial; Epidemiology; Healthcare-associated infections; Hospitals; Humans; Incidence; Intensive Care Units; Major; Methicillin-Resistant Staphylococcus aureus; Methicillin-resistant Staphylococcus aureus infection; Multidrug resistant bacteria; Multidrug resistant infection; Pandemics; SARS-CoV-2; Staphylococcal Infections - epidemiology
• ISSN: 0196-6553; 1527-3296
• DOI: 10.1016/j.ajic.2021.09.018

The impact of COVID-19 on healthcare- associated infections (HCAI) caused by multidrug-resistant (MDR) bacteria that contribute to higher mortality is a growing area of study This retrospective observational study compares the incidence density (ID) of HCAI caused by MDR bacteria (CRE, CRAB, CRP, MRSA and VRE) pre-COVID (2017-2019) and during the COVID-19 pandemic (2020) in overall hospitalized patients and in intensive care (ICU) units. We identified 8,869 HCAI, of which 2,641 (29.7%) were caused by bacterial MDR, and 1,257 (14.1%) were from ICUs. The overall ID of MDR infections increased 23% (P < .005) during COVID-19. The overall per-pathogen analysis shows significant increases in infections by CRAB and MRSA (+108.1%, p&lt;0.005; +94.7%, p&lt;0.005, respectively), but not in CRE, CRP, or VRE. In the ICU, the overall ID of MDR infections decreased during COVID, but that decline was not significant (-6.5%, P = .26). The ICU per-pathogen analysis of ID of infection showed significant increases in CRAB and MRSA (+42.0%, P = .001; +46.2%, P = .04), significant decreases in CRE and CRP (-26.4%, P = .002; -44.2%, P = 0.003, respectively) and no change in VRE. The COVID-19 pandemic correlates to an increase in ID of CRAB and MRSA both in ICU and non-ICU setting, and a decrease in ID of CRE and CRP in the ICU setting. Infection control teams should be aware of possible outbreaks of CRAB and MRSA and promote rigorous adherence to infection control measures as practices change to accommodate changes in healthcare needs during and after the pandemic. •During the COVID19 pandemic, ICU and Non-ICU patients are experiencing an increased risk of healthcare-related infections.•Hospitals treating COVID19 patients may experience outbreaks of multidrug resistant pathogens especially by MRSA and CRAB.•Infection control measures are essential in COVID19 care to decrease healthcare related infections.•COVID19 increased healthcare associated infections and the use of broad spectrum antibiotics.