Roles of Suaeda vermiculata Aqueous-Ethanolic Extract, Its Subsequent Fractions, and the Isolated Compounds in Hepatoprotection against Paracetamol-Induced Toxicity as Compared to Silymarin

Suaeda vermiculata, a halophyte consumed by livestock, is also used by Bedouins to manage liver disorders. The aqueous-ethanolic extract of S. vermiculata, its subsequent fractions, and pure compounds, i.e., pheophytin-A (1), isorhamnetin-3-O-rutinoside (2), and quercetin (3), were evaluated for the...

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Published in:Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.6174897
Main Authors: Mohammed, Salman A. A., Ali, Hussein M., Mohammed, Hamdoon A., Al-Omar, Mohsen S., Almahmoud, Suliman A., El-Readi, Mahmoud Z., Ragab, Ehab A., Sulaiman, Ghassan M., Aly, Mohamed S. A., Khan, Riaz A.
Format: Article
Language:English
Subjects:
Acetaminophen - toxicity
Analgesics
Analgesics, Non-Narcotic - toxicity
Animals
Antioxidants
Antioxidants - pharmacology
Biological activity
Biomarkers
Chenopodiaceae - chemistry
Chromatography
Cytotoxicity
Drug Interactions
Herbs
Investigations
Lipids
Liver diseases
Male
Mice
Mice, Inbred C57BL
Oxidative stress
Oxidative Stress - drug effects
Pharmacy
Plant Extracts - pharmacology
Protective Agents - pharmacology
Silymarin - pharmacology
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Summary:Suaeda vermiculata, a halophyte consumed by livestock, is also used by Bedouins to manage liver disorders. The aqueous-ethanolic extract of S. vermiculata, its subsequent fractions, and pure compounds, i.e., pheophytin-A (1), isorhamnetin-3-O-rutinoside (2), and quercetin (3), were evaluated for their hepatoprotective efficacy. The male mice were daily fed with either silymarin, plant aq.-ethanolic extract, fractions, pure isolated compounds, or carboxyl methylcellulose (CMC) for 7 days (n=6/group, p.o.). On the day 7th of the administrations, all, except the intact animal groups, were induced with hepatotoxicity using paracetamol (PCM, 300 mg/kg). The anesthetized animals were euthanized after 24 h; blood and liver tissues were collected and analysed. The serum aspartate transaminase (AST) and alanine transaminase (ALT) levels decreased significantly for all the S. vermiculata aq.-ethanolic extract, fraction, and compound-treated groups when equated with the PCM group (p
ISSN:1942-0900
1942-0994
1942-0994
DOI:10.1155/2021/6174897