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Thrombus Histology of Basilar Artery Occlusions: Are There Differences to the Anterior Circulation?
Background For patients with acute vessel occlusions of the anterior circulation histopathology of retrieved cerebral thrombi has been reported to be associated to stroke etiology. Due to the relatively small incidence of posterior circulation stroke, exclusive histopathologic analyses are missing f...
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| Published in: | Clinical neuroradiology (Munich) 2021-09, Vol.31 (3), p.753-761 |
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| container_title | Clinical neuroradiology (Munich) |
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| creator | Berndt, M. Poppert, H. Steiger, K. Pelisek, J. Oberdieck, P. Maegerlein, C. Zimmer, C. Wunderlich, S. Friedrich, B. Boeckh-Behrens, T. Ikenberg, B. |
| description | Background
For patients with acute vessel occlusions of the anterior circulation histopathology of retrieved cerebral thrombi has been reported to be associated to stroke etiology. Due to the relatively small incidence of posterior circulation stroke, exclusive histopathologic analyses are missing for this subgroup. The aim of the study was to investigate thrombus histology for patients with basilar artery occlusions and uncover differences to anterior circulation clots with respect to underlying etiology.
Methods
A total of 59 basilar thrombi were collected during intracranial mechanical recanalization and quantitatively analyzed in terms of their relative fractions of the main constituents, e.g. fibrin/platelets (F/P), red (RBC) and white blood cells (WBC). Data were compared to histopathological analyses of 122 thrombi of the anterior circulation with respect to underlying pathogenesis.
Results
The composition of basilar thrombi differed significantly to thrombi of the anterior circulation with an overall higher RBC amount (median fraction in % (interquartile range):0.48 (0.37–0.69) vs. 0.37 (0.28–0.50),
p
|
| doi_str_mv | 10.1007/s00062-020-00964-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8463366</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2448403238</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-48fd8e4dbfed05986b077d0d41f6d79efe71e475b99525c9dc275e38688cebc43</originalsourceid><addsrcrecordid>eNp9kM1Kw0AURgdRbKl9AReSpZvYSeZ_I1RRKxS6qeshmdy0KUmmziRC397R1KIbV3fgnu-7w0HoOsF3CcZi5jHGPI1ximOMFacxO0PjRHIVJ5SK89ObqBGaer8LOCZSMSYu0YiQEOaMjtFsvXW2yXsfLSrf2dpuDpEto4fMV3XmornrwB2ilTF17yvb-it0UWa1h-lxTtDb89P6cREvVy-vj_NlbAgjXUxlWUigRV5CgZmSPMdCFLigSckLoaAEkQAVLFeKpcyowqSCAZFcSgO5oWSC7ofefZ83UBhoO5fVeu-qJnMHbbNK_9201VZv7IeWlBPCeSi4PRY4-96D73RTeQN1nbVge69TSiXFJCUyoOmAGme9d1CeziRYf8nWg2wdZOtv2ZqF0M3vD54iP2oDQAbAh1W7Aad3tndtkPZf7ScAbIqs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2448403238</pqid></control><display><type>article</type><title>Thrombus Histology of Basilar Artery Occlusions: Are There Differences to the Anterior Circulation?</title><source>Springer Link</source><creator>Berndt, M. ; Poppert, H. ; Steiger, K. ; Pelisek, J. ; Oberdieck, P. ; Maegerlein, C. ; Zimmer, C. ; Wunderlich, S. ; Friedrich, B. ; Boeckh-Behrens, T. ; Ikenberg, B.</creator><creatorcontrib>Berndt, M. ; Poppert, H. ; Steiger, K. ; Pelisek, J. ; Oberdieck, P. ; Maegerlein, C. ; Zimmer, C. ; Wunderlich, S. ; Friedrich, B. ; Boeckh-Behrens, T. ; Ikenberg, B.</creatorcontrib><description>Background
For patients with acute vessel occlusions of the anterior circulation histopathology of retrieved cerebral thrombi has been reported to be associated to stroke etiology. Due to the relatively small incidence of posterior circulation stroke, exclusive histopathologic analyses are missing for this subgroup. The aim of the study was to investigate thrombus histology for patients with basilar artery occlusions and uncover differences to anterior circulation clots with respect to underlying etiology.
Methods
A total of 59 basilar thrombi were collected during intracranial mechanical recanalization and quantitatively analyzed in terms of their relative fractions of the main constituents, e.g. fibrin/platelets (F/P), red (RBC) and white blood cells (WBC). Data were compared to histopathological analyses of 122 thrombi of the anterior circulation with respect to underlying pathogenesis.
Results
The composition of basilar thrombi differed significantly to thrombi of the anterior circulation with an overall higher RBC amount (median fraction in % (interquartile range):0.48 (0.37–0.69) vs. 0.37 (0.28–0.50),
p
< 0.001) and lower F/P count (0.45 (0.21–0.58) vs. 0.57 (0.44–0.66),
p
< 0.001). Basilar thrombi composition did not differ between the different etiological stroke subgroups.
Conclusion
The results depict a differing thrombus composition of basilar thrombi in comparison to anterior circulation clots with an overall higher amount of RBC. This may reflect different pathophysiologic processes between anterior and posterior circulation thrombogenesis, e.g. a larger proportion of appositional thrombus growth in the posterior circulation.</description><identifier>ISSN: 1869-1439</identifier><identifier>EISSN: 1869-1447</identifier><identifier>DOI: 10.1007/s00062-020-00964-5</identifier><identifier>PMID: 33006654</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Basilar Artery - diagnostic imaging ; Erythrocytes ; Humans ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosurgery ; Original ; Original Article ; Stroke ; Thrombectomy ; Thrombosis - diagnostic imaging</subject><ispartof>Clinical neuroradiology (Munich), 2021-09, Vol.31 (3), p.753-761</ispartof><rights>The Author(s) 2020</rights><rights>2020. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c353t-48fd8e4dbfed05986b077d0d41f6d79efe71e475b99525c9dc275e38688cebc43</cites><orcidid>0000-0001-9124-231X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33006654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berndt, M.</creatorcontrib><creatorcontrib>Poppert, H.</creatorcontrib><creatorcontrib>Steiger, K.</creatorcontrib><creatorcontrib>Pelisek, J.</creatorcontrib><creatorcontrib>Oberdieck, P.</creatorcontrib><creatorcontrib>Maegerlein, C.</creatorcontrib><creatorcontrib>Zimmer, C.</creatorcontrib><creatorcontrib>Wunderlich, S.</creatorcontrib><creatorcontrib>Friedrich, B.</creatorcontrib><creatorcontrib>Boeckh-Behrens, T.</creatorcontrib><creatorcontrib>Ikenberg, B.</creatorcontrib><title>Thrombus Histology of Basilar Artery Occlusions: Are There Differences to the Anterior Circulation?</title><title>Clinical neuroradiology (Munich)</title><addtitle>Clin Neuroradiol</addtitle><addtitle>Clin Neuroradiol</addtitle><description>Background
For patients with acute vessel occlusions of the anterior circulation histopathology of retrieved cerebral thrombi has been reported to be associated to stroke etiology. Due to the relatively small incidence of posterior circulation stroke, exclusive histopathologic analyses are missing for this subgroup. The aim of the study was to investigate thrombus histology for patients with basilar artery occlusions and uncover differences to anterior circulation clots with respect to underlying etiology.
Methods
A total of 59 basilar thrombi were collected during intracranial mechanical recanalization and quantitatively analyzed in terms of their relative fractions of the main constituents, e.g. fibrin/platelets (F/P), red (RBC) and white blood cells (WBC). Data were compared to histopathological analyses of 122 thrombi of the anterior circulation with respect to underlying pathogenesis.
Results
The composition of basilar thrombi differed significantly to thrombi of the anterior circulation with an overall higher RBC amount (median fraction in % (interquartile range):0.48 (0.37–0.69) vs. 0.37 (0.28–0.50),
p
< 0.001) and lower F/P count (0.45 (0.21–0.58) vs. 0.57 (0.44–0.66),
p
< 0.001). Basilar thrombi composition did not differ between the different etiological stroke subgroups.
Conclusion
The results depict a differing thrombus composition of basilar thrombi in comparison to anterior circulation clots with an overall higher amount of RBC. This may reflect different pathophysiologic processes between anterior and posterior circulation thrombogenesis, e.g. a larger proportion of appositional thrombus growth in the posterior circulation.</description><subject>Basilar Artery - diagnostic imaging</subject><subject>Erythrocytes</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Original</subject><subject>Original Article</subject><subject>Stroke</subject><subject>Thrombectomy</subject><subject>Thrombosis - diagnostic imaging</subject><issn>1869-1439</issn><issn>1869-1447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM1Kw0AURgdRbKl9AReSpZvYSeZ_I1RRKxS6qeshmdy0KUmmziRC397R1KIbV3fgnu-7w0HoOsF3CcZi5jHGPI1ximOMFacxO0PjRHIVJ5SK89ObqBGaer8LOCZSMSYu0YiQEOaMjtFsvXW2yXsfLSrf2dpuDpEto4fMV3XmornrwB2ilTF17yvb-it0UWa1h-lxTtDb89P6cREvVy-vj_NlbAgjXUxlWUigRV5CgZmSPMdCFLigSckLoaAEkQAVLFeKpcyowqSCAZFcSgO5oWSC7ofefZ83UBhoO5fVeu-qJnMHbbNK_9201VZv7IeWlBPCeSi4PRY4-96D73RTeQN1nbVge69TSiXFJCUyoOmAGme9d1CeziRYf8nWg2wdZOtv2ZqF0M3vD54iP2oDQAbAh1W7Aad3tndtkPZf7ScAbIqs</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Berndt, M.</creator><creator>Poppert, H.</creator><creator>Steiger, K.</creator><creator>Pelisek, J.</creator><creator>Oberdieck, P.</creator><creator>Maegerlein, C.</creator><creator>Zimmer, C.</creator><creator>Wunderlich, S.</creator><creator>Friedrich, B.</creator><creator>Boeckh-Behrens, T.</creator><creator>Ikenberg, B.</creator><general>Springer Berlin Heidelberg</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9124-231X</orcidid></search><sort><creationdate>20210901</creationdate><title>Thrombus Histology of Basilar Artery Occlusions</title><author>Berndt, M. ; Poppert, H. ; Steiger, K. ; Pelisek, J. ; Oberdieck, P. ; Maegerlein, C. ; Zimmer, C. ; Wunderlich, S. ; Friedrich, B. ; Boeckh-Behrens, T. ; Ikenberg, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-48fd8e4dbfed05986b077d0d41f6d79efe71e475b99525c9dc275e38688cebc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Basilar Artery - diagnostic imaging</topic><topic>Erythrocytes</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Original</topic><topic>Original Article</topic><topic>Stroke</topic><topic>Thrombectomy</topic><topic>Thrombosis - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berndt, M.</creatorcontrib><creatorcontrib>Poppert, H.</creatorcontrib><creatorcontrib>Steiger, K.</creatorcontrib><creatorcontrib>Pelisek, J.</creatorcontrib><creatorcontrib>Oberdieck, P.</creatorcontrib><creatorcontrib>Maegerlein, C.</creatorcontrib><creatorcontrib>Zimmer, C.</creatorcontrib><creatorcontrib>Wunderlich, S.</creatorcontrib><creatorcontrib>Friedrich, B.</creatorcontrib><creatorcontrib>Boeckh-Behrens, T.</creatorcontrib><creatorcontrib>Ikenberg, B.</creatorcontrib><collection>SpringerOpen website</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical neuroradiology (Munich)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berndt, M.</au><au>Poppert, H.</au><au>Steiger, K.</au><au>Pelisek, J.</au><au>Oberdieck, P.</au><au>Maegerlein, C.</au><au>Zimmer, C.</au><au>Wunderlich, S.</au><au>Friedrich, B.</au><au>Boeckh-Behrens, T.</au><au>Ikenberg, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombus Histology of Basilar Artery Occlusions: Are There Differences to the Anterior Circulation?</atitle><jtitle>Clinical neuroradiology (Munich)</jtitle><stitle>Clin Neuroradiol</stitle><addtitle>Clin Neuroradiol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>31</volume><issue>3</issue><spage>753</spage><epage>761</epage><pages>753-761</pages><issn>1869-1439</issn><eissn>1869-1447</eissn><abstract>Background
For patients with acute vessel occlusions of the anterior circulation histopathology of retrieved cerebral thrombi has been reported to be associated to stroke etiology. Due to the relatively small incidence of posterior circulation stroke, exclusive histopathologic analyses are missing for this subgroup. The aim of the study was to investigate thrombus histology for patients with basilar artery occlusions and uncover differences to anterior circulation clots with respect to underlying etiology.
Methods
A total of 59 basilar thrombi were collected during intracranial mechanical recanalization and quantitatively analyzed in terms of their relative fractions of the main constituents, e.g. fibrin/platelets (F/P), red (RBC) and white blood cells (WBC). Data were compared to histopathological analyses of 122 thrombi of the anterior circulation with respect to underlying pathogenesis.
Results
The composition of basilar thrombi differed significantly to thrombi of the anterior circulation with an overall higher RBC amount (median fraction in % (interquartile range):0.48 (0.37–0.69) vs. 0.37 (0.28–0.50),
p
< 0.001) and lower F/P count (0.45 (0.21–0.58) vs. 0.57 (0.44–0.66),
p
< 0.001). Basilar thrombi composition did not differ between the different etiological stroke subgroups.
Conclusion
The results depict a differing thrombus composition of basilar thrombi in comparison to anterior circulation clots with an overall higher amount of RBC. This may reflect different pathophysiologic processes between anterior and posterior circulation thrombogenesis, e.g. a larger proportion of appositional thrombus growth in the posterior circulation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33006654</pmid><doi>10.1007/s00062-020-00964-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9124-231X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Basilar Artery - diagnostic imaging Erythrocytes Humans Medicine Medicine & Public Health Neurology Neuroradiology Neurosurgery Original Original Article Stroke Thrombectomy Thrombosis - diagnostic imaging |
| title | Thrombus Histology of Basilar Artery Occlusions: Are There Differences to the Anterior Circulation? |
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