Clinical features and risk factors of Raynaud’s phenomenon in primary Sjögren’s syndrome

• Published in: Clinical rheumatology 2021-10, Vol.40 (10), p.4081-4087
• Main Authors: Lin, Wei, Xin, Zhifei, Ning, Xiaoran, Li, Yang, Ren, Xiuying, Su, Yashuang, Liu, Meilu, Guo, Shaoying, Yang, Liu, Liu, Yixuan, Zhang, Fengxiao, Zhang, Wen
• Format: Article
• Language: English
• Subjects: Antibodies; Humans; Medical records; Medicine; Medicine & Public Health; Multivariate analysis; Original; Original Article; Patients; Phenotypes; Prospective Studies; Raynaud Disease - complications; Raynaud Disease - epidemiology; Retrospective Studies; Rheumatology; Risk Factors; Sjogren's syndrome; Sjogren's Syndrome - complications; Sjogren's Syndrome - epidemiology; Systemic sclerosis
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-021-05749-w

Objective The aim at the current study was to investigate the clinical characteristics and risk factors of Raynaud’s phenomenon (RP) in patients with primary Sjögren’s syndrome (pSS). Methods Retrospective analysis of the medical records of 333 new-onset pSS patients was performed. Demographic, clinical, and serological data were compared between individuals with and without RP. Logistic regression analysis was used to identify risk factors. Results RP was present in 11.41% of the pSS patients. pSS-RP patients were younger (49.74±14.56 years vs. 54.46±13.20 years, p =0.04) and exhibited higher disease activity (11 [5.75–15] vs. 7 [4–12], p =0.03) than those without. The prevalence of lung involvement was significantly higher in pSS patients with RP (60.53% vs. 17.29%; p