Acute Large Vessel Ischemic Stroke in Patients With COVID-19–Related Multisystem Inflammatory Syndrome

Acute ischemic stroke (AIS) is rare in children, and diagnosis is often delayed. Neurological involvement may occur in multisystem inflammatory syndrome in children (MIS-C), but very few cases of AIS in patients with MIS-C have been reported. We two patients with AIS presenting with large vessel occ...

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Bibliographic Details
Published in:Pediatric neurology 2022-01, Vol.126, p.104-107
Main Authors: Chang, Jaimie, Bulwa, Zachary, Breit, Hannah, Cherian, Laurel J., Conners, James J., Song, Sarah Y., Dafer, Rima M.
Format: Article
Language:English
Subjects:
Acute ischemic infarction
Adolescent
Clinical Observation
COVID-19
COVID-19 - complications
COVID-19 - diagnosis
COVID-19 - therapy
Female
Humans
Ischemic Stroke - diagnosis
Ischemic Stroke - therapy
Ischemic Stroke - virology
Large vessel
MIS-C
SARS-Cov2
Stroke
Systemic Inflammatory Response Syndrome - complications
Systemic Inflammatory Response Syndrome - diagnosis
Systemic Inflammatory Response Syndrome - therapy
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Summary:Acute ischemic stroke (AIS) is rare in children, and diagnosis is often delayed. Neurological involvement may occur in multisystem inflammatory syndrome in children (MIS-C), but very few cases of AIS in patients with MIS-C have been reported. We two patients with AIS presenting with large vessel occlusive disease in previously healthy adolescents recently exposed to SARS-CoV-2 infection. Both patients were subsequently diagnosed with and treated for MIS-C. Here, we discuss the course of their treatments and clinical responses. Early recognition and diagnosis of AIS with large vessel occlusion in children with MIS-C is critical to make available all treatment options to improve clinical outcomes.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2021.09.013