Untangling the relationship between negative illness perceptions and worse quality of life in patients with advanced cancer—a study from the population-based PROFILES registry

Purpose Quality of life (QoL) is an important yet complex outcome of care in patients with advanced cancer. QoL is associated with physical and psychosocial symptoms and with patients’ illness perceptions (IPs). IPs are modifiable cognitive constructs developed to make sense of one’s illness. It is...

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Bibliographic Details
Published in:Supportive care in cancer 2021-11, Vol.29 (11), p.6411-6419
Main Authors: Jabbarian, Lea J., Rietjens, Judith A. C., Mols, Floortje, Oude Groeniger, Joost, van der Heide, Agnes, Korfage, Ida J
Format: Article
Language:English
Subjects:
Analysis
Anxiety
Anxiety - epidemiology
Anxiety - etiology
Cancer
Cancer patients
Care and treatment
Depression - epidemiology
Depression - etiology
Depression, Mental
Humans
Mediation
Medicine
Medicine & Public Health
Mental depression
Mental health
Neoplasms
Nursing
Nursing Research
Oncology
Oncology, Experimental
Original
Original Article
Pain Medicine
Palliative care
Perception
Perceptions
Population-based studies
Quality of Life
Registries
Rehabilitation Medicine
Surveys and Questionnaires
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Summary:Purpose Quality of life (QoL) is an important yet complex outcome of care in patients with advanced cancer. QoL is associated with physical and psychosocial symptoms and with patients’ illness perceptions (IPs). IPs are modifiable cognitive constructs developed to make sense of one’s illness. It is unclear how IPs influence patients’ QoL. A better understanding of this relationship can inform and direct high quality care aimed at improving patients’ QoL. We therefore investigated the mediating role of anxiety and depression in the association of IPs with QoL. Methods Data from 377 patients with advanced cancer were used from the PROFILES registry. Patients completed measures on IPs (BIPQ), QoL (EORTC QLQ-C30), and symptoms of anxiety and depression (HADS). Mediation analyses were conducted to decompose the total effect of IPs on QoL into a direct effect and indirect effect. Results All IPs but one (“Comprehensibility”) were negatively associated with QoL ( p
ISSN:0941-4355
1433-7339
1433-7339
DOI:10.1007/s00520-021-06179-9