Evaluation of Sarcopenia, Frailty, and Inflammation on Adverse Events and Survival Outcomes in Patients with Oral Cavity Squamous Cell Carcinoma under Adjuvant Chemoradiotherapy

In this study, we aimed to evaluate the prognostic impact of sarcopenia, five-item modified frailty index (mFI-5), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with oral cavity squamous cell carcinoma (OSCC) treated with adjuvant chemoradiotherapy (CRT) and thei...

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Bibliographic Details
Published in:Journal of personalized medicine 2021-09, Vol.11 (9), p.936
Main Authors: Huang, Chun-Hou, Chen, Peir-Rorg, Lue, Kun-Han, Hsieh, Tsung-Cheng, Chou, Yu-Fu
Format: Article
Language:English
Subjects:
Blood
Blood platelets
Body mass index
Cancer therapies
Chemoradiotherapy
Chemotherapy
Clinical outcomes
Frailty
Head & neck cancer
Inflammation
Laboratories
Leukocytes (neutrophilic)
Lymphocytes
Medical prognosis
Medical records
Musculoskeletal system
Neutrophils
Oral carcinoma
Oral cavity
Patients
Precision medicine
Radiation therapy
Regression analysis
Sarcopenia
Squamous cell carcinoma
Surgery
Survival analysis
Toxicity
Vertebrae
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Summary:In this study, we aimed to evaluate the prognostic impact of sarcopenia, five-item modified frailty index (mFI-5), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with oral cavity squamous cell carcinoma (OSCC) treated with adjuvant chemoradiotherapy (CRT) and their survival outcomes. We retrospectively enrolled 175 patients with OSCC undergoing adjuvant CRT between 2011 and 2018, who were divided into groups with (n = 112) and without (n = 63) sarcopenia. Logistic regression analysis and Cox proportional hazards models were used to determine prognostic factors for CRT-related toxicity, three-year overall survival (OS), and disease-free survival (DFS). Sarcopenia and high PLR were independently associated with CRT-induced anemia (CIA); advanced tumor stage was related to poor three-year OS. CRT and survival did not differ by mFI-5 and NLR. Our results indicate that sarcopenia and high PLR are significant predictors of adjuvant CRT, increasing toxicity outcomes and indicating worse short-term OS. Accurately identifying sarcopenia and high PLR in patients with OSCC is critical to help better select candidates for adjuvant CRT to improve their outcomes.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11090936