The Aggregate Index of Systemic Inflammation (AISI): A Novel Prognostic Biomarker in Idiopathic Pulmonary Fibrosis

Variable patterns of disease progression are typically observed in patients with idiopathic pulmonary fibrosis (IPF). We sought to determine the prognostic capacity of blood cell count indexes, derived from routine complete blood cell (CBC) count, in a cohort of IPF patients. The neutrophil-to-lymph...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-09, Vol.10 (18), p.4134
Main Authors: Zinellu, Angelo, Collu, Claudia, Nasser, Mouhamad, Paliogiannis, Panagiotis, Mellino, Sabrina, Zinellu, Elisabetta, Traclet, Julie, Ahmad, Kais, Mangoni, Arduino Aleksander, Carru, Ciriaco, Pirina, Pietro, Fois, Alessandro Giuseppe, Cottin, Vincent
Format: Article
Language:English
Subjects:
Age
Biomarkers
Blood
Blood platelets
Body mass index
Chronic illnesses
Chronic obstructive pulmonary disease
Clinical medicine
Correlation analysis
Drugs
Gender
Hematology
Human health and pathology
Inflammation
Life Sciences
Lung diseases
Lymphocytes
Medical prognosis
Mortality
Neutrophils
Pulmonary fibrosis
Survival analysis
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Summary:Variable patterns of disease progression are typically observed in patients with idiopathic pulmonary fibrosis (IPF). We sought to determine the prognostic capacity of blood cell count indexes, derived from routine complete blood cell (CBC) count, in a cohort of IPF patients. The neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) were calculated at baseline in a consecutive series of 82 IPF patients followed for four years. After adjusting for age, gender, body mass index, smoking status, and disease stage, only the AISI was significantly associated with mortality (HR 1.0013, 95% CI 1.0003–1.0023, p = 0.015). Patients with AISI
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10184134