Upregulation of CCL7, CCL20, CXCL2, IL-1β, IL-6 and MMP-9 in Skin Samples of PCB Exposed Individuals—A Preliminary Study

Polychlorinated biphenyls (PCBs) are well known immunotoxic and carcinogenic compounds. Although cutaneous symptoms are the hallmark of exposure to these compounds, exact pathophysiologic mechanisms are not well understood. We took skin biopsies from moderately high PCB exposed workers (n = 25) afte...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-09, Vol.18 (18), p.9711
Main Authors: Leijs, Marike, Fietkau, Katharina, Merk, Hans F., Schettgen, Thomas, Kraus, Thomas, Esser, André
Format: Article
Language:English
Subjects:
Acne
Carcinogenesis
Carcinogens
CCL20 protein
Dioxins
Exposure
Gelatinase B
Genes
IL-1β
Immunology
Inflammatory diseases
Informed consent
Interleukin 6
Kinases
Matrix metalloproteinase
Matrix metalloproteinases
Metalloproteinase
Occupational exposure
PCB
Polychlorinated biphenyls
Serum levels
Signs and symptoms
Skin
Statistical analysis
Statistical methods
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Summary:Polychlorinated biphenyls (PCBs) are well known immunotoxic and carcinogenic compounds. Although cutaneous symptoms are the hallmark of exposure to these compounds, exact pathophysiologic mechanisms are not well understood. We took skin biopsies from moderately high PCB exposed workers (n = 25) after an informed consent and investigated the expression of immunological markers such as CCL-7, CCL-20, CXCL2, IL-1β and IL-6, as well as the matrix metalloproteinase MMP-9, EPGN and NRF2 by RT-qPCR, and compared expression levels with plasma PCB levels. Statistical analyses showed a significant correlation between CCL-20, CXCL2, IL-6, IL-1β, CCL-7 and MMP-9 and PCB serum levels. EPGN and NRF2 were not correlated to PCB levels in the blood. We found a significant correlation of genes involved in autoimmune, auto-inflammatory and carcinogenesis in skin samples of PCB exposed individuals with elevated plasma PCB levels. Confirmation of these findings needs to be performed in bigger study groups and larger gen-sets, including multiple housekeeping genes. Further study needs to be performed to see whether a chronical exposure to these and similar compounds can cause higher incidence of malignancies and inflammatory disease.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18189711