Chronic Myeloid Leukemia in Children: Immune Function and Vaccinations

Children with CML need TKI treatment for many years, and the lack of knowledge about immune dysfunction with TKI has hindered routine immunizations. This review attempts to provide an overview of the effects of TKIs licensed for children (e.g., imatinib, dasatinib, and nilotinib) on immune function,...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-09, Vol.10 (18), p.4056
Main Authors: Suttorp, Meinolf, Webster Carrion, Andrea, Hijiya, Nobuko
Format: Article
Language:English
Subjects:
Adults
Antibodies
Clinical medicine
Dendritic cells
Disease prevention
Hepatitis B
Immunoglobulins
Influenza
Leukemia
Patients
Pediatrics
Review
Streptococcus infections
Vaccines
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Summary:Children with CML need TKI treatment for many years, and the lack of knowledge about immune dysfunction with TKI has hindered routine immunizations. This review attempts to provide an overview of the effects of TKIs licensed for children (e.g., imatinib, dasatinib, and nilotinib) on immune function, as well as its implications on immunizations. We discuss surveillance strategies (e.g., immunoglobulin blood serum levels and hepatitis B reactivation) and immunizations. All inactivated vaccines (e.g., influenza, pneumococcal, and streptococcal) can be given during the treatment of CML in the chronic phase, although their efficacy may be lower. As shown in single cases of children and adults with CML, live vaccines (e.g., varicella, measles, mumps, rubella, and yellow fever) may be administered under defined circumstances with great precautions. We also highlight important aspects of COVID-19 in this patient population (e.g., the outcome of COVID-19 infection in adults with CML and in children with varying hemato-oncological diseases) and discuss the highly dynamic field of presently available different vaccination options. In conclusion, TKI treatment for CML causes humoral and cellular immune dysfunction, which is mild in most patients, and thus infectious complications are rare. Routine immunizations are important for health maintenance of children, but vaccinations for children with CML on TKI therapy should be carefully considered.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10184056