Metachronous Esophageal Ulcers after Immune-mediated Colitis Due to Immune Checkpoint Inhibitor Therapy: A Case Report and Literature Review

Although cases of gastrointestinal toxicity of pembrolizumab have been reported, cases of acute immune-mediated colitis accompanied with metachronous esophageal disorders (esophagitis and ulcer) are rare. We herein report a case of acute colitis and metachronous esophageal ulcers due to an immune-re...

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Bibliographic Details
Published in:Internal Medicine 2021/09/01, Vol.60(17), pp.2783-2791
Main Authors: Ogawa, Soichiro, Kawakami, Hiroshi, Suzuki, Sho, Kuroki, Daisuke, Uchiyama, Naomi, Hatada, Hiroshi, Gi, Toshihiro, Sato, Yuichiro
Format: Article
Language:English
Subjects:
Adenocarcinoma
Case Report
Case reports
Chemotherapy
Colitis
Esophagitis
Esophagus
ICI
Immune checkpoint
immune-mediated colitis
Inflammatory bowel disease
Internal medicine
Literature reviews
metachronous esophageal ulcer
Pembrolizumab
steroid administration
Toxicity
Ulcers
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Description
Summary:Although cases of gastrointestinal toxicity of pembrolizumab have been reported, cases of acute immune-mediated colitis accompanied with metachronous esophageal disorders (esophagitis and ulcer) are rare. We herein report a case of acute colitis and metachronous esophageal ulcers due to an immune-related adverse event following concomitant pembrolizumab chemotherapy for lung adenocarcinoma. To our knowledge, there have so far been no reports of cases in which both acute immune-mediated colitis and metachronous esophageal ulcers developed. We therefore report the details of this case along with a review of the pertinent literature.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.6606-20