In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide

Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties via a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GG...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2021-09, Vol.12 (37), p.12266-12273
Main Authors: Ahmadi, Peni, Muguruma, Kyohei, Chang, Tsung-Che, Tamura, Satoru, Tsubokura, Kazuki, Egawa, Yasuko, Suzuki, Takehiro, Dohmae, Naoshi, Nakao, Yoichi, Tanaka, Katsunori
Format: Article
Language:English
Subjects:
Alkylation
Apoptosis
Cancer
Cancer therapies
Chemistry
Marking
Peptides
Ruthenium compounds
Therapy
Tumors
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Summary:Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties via a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent therapeutic effects both in vitro and in vivo . In particular, co-treatment with proapoptotic peptide and the carrier–Ru complex significantly and synergistically inhibited tumor growth and prolonged survival rate of tumor-bearing mice after only a single injection. This is the first report of Ru catalyst application in vivo , and this approach could be used in SeCT for cancer therapy.
ISSN:2041-6520
2041-6539
DOI:10.1039/d1sc01784e