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In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide
Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties via a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GG...
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| Published in: | Chemical science (Cambridge) 2021-09, Vol.12 (37), p.12266-12273 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 12273 |
| container_issue | 37 |
| container_start_page | 12266 |
| container_title | Chemical science (Cambridge) |
| container_volume | 12 |
| creator | Ahmadi, Peni Muguruma, Kyohei Chang, Tsung-Che Tamura, Satoru Tsubokura, Kazuki Egawa, Yasuko Suzuki, Takehiro Dohmae, Naoshi Nakao, Yoichi Tanaka, Katsunori |
| description | Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties
via
a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent therapeutic effects both
in vitro
and
in vivo
. In particular, co-treatment with proapoptotic peptide and the carrier–Ru complex significantly and synergistically inhibited tumor growth and prolonged survival rate of tumor-bearing mice after only a single injection. This is the first report of Ru catalyst application
in vivo
, and this approach could be used in SeCT for cancer therapy. |
| doi_str_mv | 10.1039/d1sc01784e |
| format | article |
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via
a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent therapeutic effects both
in vitro
and
in vivo
. In particular, co-treatment with proapoptotic peptide and the carrier–Ru complex significantly and synergistically inhibited tumor growth and prolonged survival rate of tumor-bearing mice after only a single injection. This is the first report of Ru catalyst application
in vivo
, and this approach could be used in SeCT for cancer therapy.</description><identifier>ISSN: 2041-6520</identifier><identifier>EISSN: 2041-6539</identifier><identifier>DOI: 10.1039/d1sc01784e</identifier><identifier>PMID: 34603656</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Alkylation ; Apoptosis ; Cancer ; Cancer therapies ; Chemistry ; Marking ; Peptides ; Ruthenium compounds ; Therapy ; Tumors</subject><ispartof>Chemical science (Cambridge), 2021-09, Vol.12 (37), p.12266-12273</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><rights>This journal is © The Royal Society of Chemistry 2021 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-f2969703272ddc7e3089799962ccc85a85b0526b8ac5fd5c5ecfe76fd1a9d0ed3</citedby><cites>FETCH-LOGICAL-c423t-f2969703272ddc7e3089799962ccc85a85b0526b8ac5fd5c5ecfe76fd1a9d0ed3</cites><orcidid>0000-0001-6932-4802</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480321/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480321/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Ahmadi, Peni</creatorcontrib><creatorcontrib>Muguruma, Kyohei</creatorcontrib><creatorcontrib>Chang, Tsung-Che</creatorcontrib><creatorcontrib>Tamura, Satoru</creatorcontrib><creatorcontrib>Tsubokura, Kazuki</creatorcontrib><creatorcontrib>Egawa, Yasuko</creatorcontrib><creatorcontrib>Suzuki, Takehiro</creatorcontrib><creatorcontrib>Dohmae, Naoshi</creatorcontrib><creatorcontrib>Nakao, Yoichi</creatorcontrib><creatorcontrib>Tanaka, Katsunori</creatorcontrib><title>In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide</title><title>Chemical science (Cambridge)</title><description>Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties
via
a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent therapeutic effects both
in vitro
and
in vivo
. In particular, co-treatment with proapoptotic peptide and the carrier–Ru complex significantly and synergistically inhibited tumor growth and prolonged survival rate of tumor-bearing mice after only a single injection. This is the first report of Ru catalyst application
in vivo
, and this approach could be used in SeCT for cancer therapy.</description><subject>Alkylation</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemistry</subject><subject>Marking</subject><subject>Peptides</subject><subject>Ruthenium compounds</subject><subject>Therapy</subject><subject>Tumors</subject><issn>2041-6520</issn><issn>2041-6539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkU1LAzEQhoMottRe_AULXkRYzccm2VwKUqsWCh5azyFNZu2W7WZNtoX6691aKegcZgbm4Z0ZXoSuCb4nmKkHR6LFROYZnKE-xRlJBWfq_NRT3EPDGNe4C8YIp_IS9VgmMBNc9NFoWie7cueTDbSmSq3p8v4LXDKH8SJpVxBMs0-W-8QkTfCm8U3r29ImDTRt6eAKXRSmijD8rQP0_jxZjF_T2dvLdPw4S21GWZsWVAklMaOSOmclMJwrqZQS1Fqbc5PzJeZULHNjeeG45WALkKJwxCiHwbEBGh11m-1yA85C3QZT6SaUGxP22ptS_53U5Up_-J3Os7xbSzqB21-B4D-3EFu9KaOFqjI1-G3UlEuFFZFcdOjNP3Ttt6Hu3jtQMuOKCtpRd0fKBh9jgOJ0DMH64Ix-IvPxjzMT9g33hH7b</recordid><startdate>20210929</startdate><enddate>20210929</enddate><creator>Ahmadi, Peni</creator><creator>Muguruma, Kyohei</creator><creator>Chang, Tsung-Che</creator><creator>Tamura, Satoru</creator><creator>Tsubokura, Kazuki</creator><creator>Egawa, Yasuko</creator><creator>Suzuki, Takehiro</creator><creator>Dohmae, Naoshi</creator><creator>Nakao, Yoichi</creator><creator>Tanaka, Katsunori</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6932-4802</orcidid></search><sort><creationdate>20210929</creationdate><title>In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide</title><author>Ahmadi, Peni ; Muguruma, Kyohei ; Chang, Tsung-Che ; Tamura, Satoru ; Tsubokura, Kazuki ; Egawa, Yasuko ; Suzuki, Takehiro ; Dohmae, Naoshi ; Nakao, Yoichi ; Tanaka, Katsunori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-f2969703272ddc7e3089799962ccc85a85b0526b8ac5fd5c5ecfe76fd1a9d0ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alkylation</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemistry</topic><topic>Marking</topic><topic>Peptides</topic><topic>Ruthenium compounds</topic><topic>Therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmadi, Peni</creatorcontrib><creatorcontrib>Muguruma, Kyohei</creatorcontrib><creatorcontrib>Chang, Tsung-Che</creatorcontrib><creatorcontrib>Tamura, Satoru</creatorcontrib><creatorcontrib>Tsubokura, Kazuki</creatorcontrib><creatorcontrib>Egawa, Yasuko</creatorcontrib><creatorcontrib>Suzuki, Takehiro</creatorcontrib><creatorcontrib>Dohmae, Naoshi</creatorcontrib><creatorcontrib>Nakao, Yoichi</creatorcontrib><creatorcontrib>Tanaka, Katsunori</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical science (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmadi, Peni</au><au>Muguruma, Kyohei</au><au>Chang, Tsung-Che</au><au>Tamura, Satoru</au><au>Tsubokura, Kazuki</au><au>Egawa, Yasuko</au><au>Suzuki, Takehiro</au><au>Dohmae, Naoshi</au><au>Nakao, Yoichi</au><au>Tanaka, Katsunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide</atitle><jtitle>Chemical science (Cambridge)</jtitle><date>2021-09-29</date><risdate>2021</risdate><volume>12</volume><issue>37</issue><spage>12266</spage><epage>12273</epage><pages>12266-12273</pages><issn>2041-6520</issn><eissn>2041-6539</eissn><abstract>Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties
via
a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent therapeutic effects both
in vitro
and
in vivo
. In particular, co-treatment with proapoptotic peptide and the carrier–Ru complex significantly and synergistically inhibited tumor growth and prolonged survival rate of tumor-bearing mice after only a single injection. This is the first report of Ru catalyst application
in vivo
, and this approach could be used in SeCT for cancer therapy.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><pmid>34603656</pmid><doi>10.1039/d1sc01784e</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6932-4802</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical science (Cambridge), 2021-09, Vol.12 (37), p.12266-12273 |
| issn | 2041-6520 2041-6539 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8480321 |
| source | PubMed Central(OpenAccess) |
| subjects | Alkylation Apoptosis Cancer Cancer therapies Chemistry Marking Peptides Ruthenium compounds Therapy Tumors |
| title | In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide |
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