Polyglutamic acid grafted dopamine modified collagen-polyvinyl alcohol hydrogel for a potential wound dressing

Natural collagen has good biocompatibility and ability to promote tissue regeneration and repair, but the poor mechanical properties and intolerance of degradation of natural collagen limit its applications in the biomedical field. In this research, we synthesized a skin wound repair hydrogel with g...

Full description

Saved in:
Bibliographic Details
Published in:Designed monomers and polymers 2021-01, Vol.24 (1), p.293-304
Main Authors: Yu, Guofei, Yang, Changkai, Dan, Nianhua, Dan, Weihua, Chen, Yining
Format: Article
Language:English
Subjects:
Biocompatibility
Biological activity
Biomedical materials
Cell adhesion
Collagen
Collagen pga hydrogel water-absorbing
Crosslinking
Dopamine
Full Length
Hydrogels
Mechanical properties
Polyvinyl alcohol
Regeneration
Repair
Synthesis
Tissue engineering
Water absorption
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Natural collagen has good biocompatibility and ability to promote tissue regeneration and repair, but the poor mechanical properties and intolerance of degradation of natural collagen limit its applications in the biomedical field. In this research, we synthesized a skin wound repair hydrogel with good biological activity, high strength and excellent water absorption properties. Inspired by the theory of wet healing, dopamine was introduced into the side chain of the water-absorbing polymer polyglutamic acid to synthesize a cross-linking agent (PGAD) with both water absorption and cell adhesion ablities, and then it was introduced into collagen/polyvinyl alcohol (PVA-COL) system to form a double network hydrogel. Scanning electron microscope observation of the morphological characteristics of the hydrogel showed that after the introduction of PGAD, the hydrogel formed an obvious pore structure, and the swelling rate showed that the introduction of PGAD significantly improved the water absorption rate of the hydrogel.In addition, PVA-COL-PGAD hydrogel has good mechanical properties and water absorption behavior.In vitro experimental results revealed that the hydrogel has good biocompatibility. In vivo wound healing experiments showed that hydrogel can promote wound healing process.These results indicated that our hydrogel has great potential as a medical wound dressing.
ISSN:1385-772X
1568-5551
1568-5551
DOI:10.1080/15685551.2021.1984007