Inflammatory Proteins as Molecular Markers in the Diagnosis of Cervical Oncopathology

• Published in: Sovremennye tekhnologii v medit͡s︡ine 2021-01, Vol.13 (4), p.64-68
• Main Authors: Kayukova, E V, Sholokhov, L F, Ziganshin, A M, Mudrov, V A
• Format: Article
• Language: English
• Subjects: Cervix Uteri - metabolism; Clinical Supplements; Early Detection of Cancer - methods; Female; Humans; Prospective Studies; Uterine Cervical Dysplasia - diagnosis; Vaginal Smears - methods
• ISSN: 2076-4243; 2309-995X
• DOI: 10.17691/stm2021.13.4.07

Imperfection of cytological diagnostics of cervical cancer has prompted the search for alternative methods of pathology detection. was to evaluate the effectiveness of inflammatory proteins as molecular markers in the diagnosis of cervical oncopathology. A prospective controlled trial was conducted with three groups of women: group 1 (n=13) - with precancerous pathology (cervical intraepithelial neoplasia of grade III); group 2 (n=49) - patients with cervical cancer; group 3, control (n=13) - gynecologically healthy women (mean age - 30.0±4.4 years).The material for the study was cervical epithelium, which was taken according to the standard technique using a cytobrush from the junction zone of cervical. The levels of inflammatory proteins (SAA, ICAM-1, VCAM-1, and sCD27) in the cervical epithelium were determined by flow cytometry. Molecular criteria for the presence of precancerous pathology and cervical cancer have been found to be a 3.10 [1.31; 3.28] fold increase in SAA values (U=41.0, p=0.02), 2.62 [2.79 3.50] fold (U=137.0, p=0.001) in ICAM-1, 5.20 [3.84; 12.37] fold (U=138.5, p=0.001) in VCAM-1, and 4.32 [2.07; 5.02] fold (U=109.0, p