Cerebral Hemodynamics and Executive Function in Sickle Cell Anemia

Individuals with sickle cell anemia experience cognitive deficits, even in the absence of cerebral infarcts or strokes. This study tested the hypothesis that elevated cerebral blood flow and oxygen extraction fraction are associated with lower executive function in individuals with sickle cell anemi...

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Bibliographic Details
Published in:Stroke (1970) 2021-05, Vol.52 (5), p.1830-1834
Main Authors: Prussien, Kemar V., Compas, Bruce E., Siciliano, Rachel E., Ciriegio, Abagail E., Lee, Chelsea A., Kassim, Adetola A., DeBaun, Michael R., Donahue, Manus J., Jordan, Lori C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - diagnostic imaging
Anemia, Sickle Cell - physiopathology
Anemia, Sickle Cell - psychology
Brain - diagnostic imaging
Brain - physiopathology
Cerebrovascular Circulation - physiology
Child
Cognition - physiology
Executive Function - physiology
Female
Hemodynamics - physiology
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term - physiology
Neuropsychological Tests
Young Adult
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Summary:Individuals with sickle cell anemia experience cognitive deficits, even in the absence of cerebral infarcts or strokes. This study tested the hypothesis that elevated cerebral blood flow and oxygen extraction fraction are associated with lower executive function in individuals with sickle cell anemia. Three-Tesla brain magnetic resonance imaging was performed, including anatomic, gray matter cerebral blood flow, and global oxygen extraction fraction imaging. Executive function was measured using the working memory index from an age-appropriate Wechsler battery and tasks from the National Institutes of Health Toolbox Cognition Battery. Bivariate and multivariate models were examined (significance:
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.120.032741