Fracture Incidence and the Relevance of Dietary and Lifestyle Factors Differ in the United Kingdom and Hong Kong: An International Comparison of Longitudinal Cohort Study Data

Geographic variation in fracture risk may be due to divergent profiles of dietary, lifestyle, and other risk factors between populations. We investigated differences in fracture rates between two older-population cohorts: the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfol...

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Bibliographic Details
Published in:Calcified tissue international 2021-11, Vol.109 (5), p.563-576
Main Authors: Hayhoe, Richard P. G., Chan, Ruth, Skinner, Jane, Leung, Jason, Jennings, Amy, Khaw, Kay-Tee, Woo, Jean, Welch, Ailsa A.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cohort analysis
Cohort Studies
Endocrinology
Female
Fractures
Geographical variations
Hip
Hip Fractures
Hong Kong - epidemiology
Humans
Incidence
Life Sciences
Life Style
Longitudinal Studies
Male
Original Research
Orthopedics
Osteoporosis
Prospective Studies
Public health
Regression analysis
Risk Factors
United Kingdom - epidemiology
Wrist
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Summary:Geographic variation in fracture risk may be due to divergent profiles of dietary, lifestyle, and other risk factors between populations. We investigated differences in fracture rates between two older-population cohorts: the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk cohort ( n  = 7732) in the United Kingdom (UK), and the Mr and Ms Os cohort ( n  = 3956) in Hong Kong (HK). Data were collected by questionnaires, laboratory assessments, and hospital records. Incidence of hip, spine, and wrist fractures in the two cohorts was calculated and multivariable regression was used to explore variables important to fracture risk. Total hip, spine, and wrist fracture incidence was higher in the UK vs HK for women (13.70 vs 8.76 per 1000 person-years; p  
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-021-00870-z