Seroprevalence of IgM and IgG Antibodies against SARS-CoV-2 in Asymptomatic People in Wuhan: Data from a General Hospital Near South China Seafood Wholesale Market during March to April in 2020

The aim of this study was to estimate the seroprevalence of immunoglobulin M (IgM) and G (IgG) antibodies against SARS-CoV-2 in asymptomatic people in Wuhan. This was a cross-sectional study, which enrolled 18,712 asymptomatic participants from 154 work units in Wuhan. Pearson Chi-square test, -test...

Full description

Saved in:
Bibliographic Details
Published in:Biomedical and environmental sciences 2021-09, Vol.34 (9), p.743-749
Main Authors: LING, Rui Jie, YU, Yi Han, HE, Jia Yu, ZHANG, Ji Xian, XU, Sha, SUN, Ren Rong, ZHU, Wang Cai, CHEN, Ming Feng, LI, Tao, JI, Hong Long, WANG, Huan Qiang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral - blood
Carrier State - epidemiology
Carrier State - immunology
Child
Child, Preschool
China - epidemiology
Coronavirus Nucleocapsid Proteins - immunology
COVID-19 - epidemiology
COVID-19 - immunology
Cross-Sectional Studies
Female
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Letter to the Editor
Male
Middle Aged
Occupations - classification
Phosphoproteins - immunology
SARS-CoV-2 - immunology
Seroepidemiologic Studies
Spike Glycoprotein, Coronavirus - immunology
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to estimate the seroprevalence of immunoglobulin M (IgM) and G (IgG) antibodies against SARS-CoV-2 in asymptomatic people in Wuhan. This was a cross-sectional study, which enrolled 18,712 asymptomatic participants from 154 work units in Wuhan. Pearson Chi-square test, -test, and Mann-Whitney test were used to compare the standardized seroprevalence of IgG and IgM for age and gender between different groups. The results indicated the standardized seroprevalence of IgG and IgM showed a downward trend and was significantly higher among females than males. Besides, different geographic areas and workplaces had different seroprevalence of IgG among asymptomatic people, and the number of abnormalities in CT imaging were higher in IgG antibody-positive cases than IgG-negative cases. We hope these findings can provide references for herd immunity investigation and provide basis for vaccine development.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2021.103