Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection

Influenza A viruses (IAVs) are contagious pathogens and one of the leading causes of respiratory tract infections in both humans and animals worldwide. Upon infection, the innate immune system provides the first line of defense to neutralize or limit the replication of invading pathogens, creating a...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2021-10, Vol.11 (10), p.a038414
Main Authors: Muñoz-Moreno, Raquel, Martínez-Romero, Carles, García-Sastre, Adolfo
Format: Article
Language:English
Subjects:
Humans
Immune Evasion - immunology
Influenza A virus - drug effects
Influenza, Human
Interferon Type I - therapeutic use
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Summary:Influenza A viruses (IAVs) are contagious pathogens and one of the leading causes of respiratory tract infections in both humans and animals worldwide. Upon infection, the innate immune system provides the first line of defense to neutralize or limit the replication of invading pathogens, creating a fast and broad response that brings the cells into an alerted state through the secretion of cytokines and the induction of the interferon (IFN) pathway. At the same time, IAVs have developed a plethora of immune evasion mechanisms in order to avoid or circumvent the host antiviral response, promoting viral replication. Herein, we will review and summarize already known and recently described innate immune mechanisms that host cells use to fight IAV viral infections as well as the main strategies developed by IAVs to overcome such powerful defenses during this fascinating virus-host interplay.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a038414