Analysis of ENAM gene single-nucleotide polymorphism rs3796704 with caries susceptibility in young adult Tamil population

Dental caries is as primeval as humanity, but still, investigations are undergoing regarding the etiopathogenesis behind this multifactorial disease. Genetics is known to play a vital role in the etiology behind dental caries in addition to environmental and socioeconomic factors. Genetic variations...

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Bibliographic Details
Published in:Journal of oral and maxillofacial pathology : JOMFP 2021-05, Vol.25 (2), p.226-231
Main Authors: Thampan, Niveditha, Ramya, R, Swarnalakshmi, R, Rajkumar, K, Savithri, S, Divyalakshmi, G
Format: Article
Language:English
Subjects:
Analysis
Dental caries
Disease susceptibility
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Original
Single nucleotide polymorphisms
Teenagers
Youth
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Summary:Dental caries is as primeval as humanity, but still, investigations are undergoing regarding the etiopathogenesis behind this multifactorial disease. Genetics is known to play a vital role in the etiology behind dental caries in addition to environmental and socioeconomic factors. Genetic variations like single-nucleotide polymorphisms (SNPs) were extensively studied in the past decade to portray the etiopathogenesis contributing to dental caries. This investigation was undertaken to analyze the ENAM gene SNP rs3796704 with caries susceptibility in ethnic young adult Tamil population of India. Out of 370 patients included, 215 patients belonged to the high caries group (Decayed, Missing and Filled Tooth [DMFT] ≥2) and 155 patients belonged to the low caries group (DMFT ≤ 1). DNA was extracted from the blood of all the individuals. SNP genotyping was performed utilizing tetra-primer amplification refractory mutation system-polymerase chain reaction with specific primers. The genotyping results showed that there were no differences in allelic ( = 0.114) and genotypic frequencies ( = 0.159) between the high caries and low caries groups. Future studies can be conducted in larger samples and different ethnicities around the globe to analyze the role played by SNPs of enamel formation genes in cariogenesis.
ISSN:0973-029X
1998-393X
DOI:10.4103/0973-029X.325119