Secretory carcinoma of salivary gland - A systematic review of pediatric case reports and case series

Mammary analog secretory carcinoma (MASC) is a new pathological entity of salivary gland origin recognized as Secretory Carcinoma (SC) in the WHO 2017 classification. Pediatric cases of MASC were reviewed systematically from 2010 to 2019. Databases were searched from 2010 to 2019 for pediatric case...

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Bibliographic Details
Published in:Journal of oral and maxillofacial pathology : JOMFP 2021-05, Vol.25 (2), p.327-331
Main Authors: Vasanthi, V, Ramadoss, R
Format: Article
Language:English
Subjects:
Cancer
Carcinoma
Children
Health aspects
Pediatrics
Review
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Summary:Mammary analog secretory carcinoma (MASC) is a new pathological entity of salivary gland origin recognized as Secretory Carcinoma (SC) in the WHO 2017 classification. Pediatric cases of MASC were reviewed systematically from 2010 to 2019. Databases were searched from 2010 to 2019 for pediatric case reports and case series, excluding retrospective studies. A total of 12 manuscripts were reviewed for clinical, histological and immunohistochemical findings. A total of 13 pediatric cases (11 case reports and 1 case series of 2 cases) of MASC in pediatric patients were found. The youngest reported age was 5 years. The common site was parotid gland usually presenting as a slowly growing firm, painless mass. MASC should be considered in the differential diagnosis of salivary gland tumors in pediatric population, especially from parotid gland. Extended research on such recent entities with more inputs from new cases reported in literature may outstretch the possibilities of therapeutic fusion inhibition in future.
ISSN:0973-029X
1998-393X
DOI:10.4103/0973-029X.325236