From biomineralization to tumorogenesis-the expanding insight of the physiological and pathological roles of Fam20C

Fam20C is a Golgi kinase phosphorylating the majority of the secreted proteins. In this decade, the function of Fam20C has been largely disclosed in the loss-of function models. How the influence of the overexpressed Fam20C on cells or organs, and whether Fam20C was associated with tumorogensis stil...

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Bibliographic Details
Published in:Bioscience reports 2021-05, Vol.41 (5)
Main Authors: Wu, Yanbing, Wang, Haoru, Liu, Chao
Format: Article
Language:English
Subjects:
Biomineralization
Cancer
Cancer therapies
Casein Kinase I - metabolism
Commentaries
Enzymes
Extracellular Matrix Proteins
Golgi apparatus
Golgi Apparatus - metabolism
Humans
Hypotheses
Immune system
Kinases
Metastases
Mineralization
Molecular Bases of Health & Disease
Mutation
Phosphorylation
Physiology
Prognosis
Proteins
Rickets
Roles
Signal transduction
Structural Biology
Transgenic animals
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Summary:Fam20C is a Golgi kinase phosphorylating the majority of the secreted proteins. In this decade, the function of Fam20C has been largely disclosed in the loss-of function models. How the influence of the overexpressed Fam20C on cells or organs, and whether Fam20C was associated with tumorogensis still remain unknown. In the latest article in Bioscience Reports, a group from The Second Affiliated Hospital of Harbin Medical University established a correlation between the elevated Fam20C expression and the poor prognosis of multiple cancers (Biosci. Rep. (2021), 41(1) BSR20201920). In addition, they also proposed the potential mechanisms how the increased Fam20C expression played a detrimental role in tumor progression by suggesting that the up-regulated Fam20C level affected the infiltration of immune cells and the capability of cancer metastasis. To give an overview of the expanding knowledge of Fam20C involved in the physiological and pathological events, we first reviewed the history of Fam20C study in this commentary, then, evaluated the correlation of the elevated Fam20C expression to the prognosis of multiple cancers, and finally, interpreted the perspectives that the Fam20C gain-of-function model was also critical for cancer therapy.
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20210040