Evidence That Blunted CD4 T-Cell Responses Underlie Deficient Protective Antibody Responses to Influenza Vaccines in Repeatedly Vaccinated Human Subjects

Abstract Despite the benefits of yearly influenza vaccination, accumulating evidence suggests that diminished vaccine efficacy may be related to repeated vaccination. Although studied at the level of B-cell responses, CD4 T-cell responses have not yet been examined. In this study, we analyze CD4 T-c...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2020-06, Vol.222 (2), p.273-277
Main Authors: Richards, Katherine A, Shannon, Ian, Treanor, John J, Yang, Hongmei, Nayak, Jennifer L, Sant, Andrea J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies
Antibodies, Viral - biosynthesis
Antibodies, Viral - blood
CD4 antigen
CD4-Positive T-Lymphocytes - immunology
Editor's Choice
Hemagglutinin Glycoproteins, Influenza Virus - immunology
Humans
Immunization
Immunogenicity, Vaccine
Influenza
Influenza A virus - immunology
Influenza B virus - immunology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Lymphocytes B
Lymphocytes T
Major and Brief Reports
Middle Aged
Orthomyxoviridae - immunology
T Follicular Helper Cells - immunology
Vaccination
Vaccine efficacy
Vaccines
Vaccines, Inactivated - immunology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Despite the benefits of yearly influenza vaccination, accumulating evidence suggests that diminished vaccine efficacy may be related to repeated vaccination. Although studied at the level of B-cell responses, CD4 T-cell responses have not yet been examined. In this study, we analyze CD4 T-cell responses to influenza vaccination in subjects who differ in their vaccine history. We find a striking disparity in their responses, with previously vaccinated subjects exhibiting significantly blunted CD4 T-cell responses and diminished antibody responses. These results suggest that limiting CD4 T-cell help mteaserrlie the diminished or altered antibody responses in repeatedly vaccinated subjects. Antibody responses to influenza vaccines are often diminished in individuals who are repeatedly vaccinated. Here, we discovered that requisite CD4 T-cell responses are similarly reduced, suggesting that early events in vaccine-induced immunity are blunted in repeatedly vaccinated subjects.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiz433