Metabolomics-Based Clinical Efficacy of Compound Shenlu Granule, a Chinese Patent Medicine, in the Supportive Management of Aplastic Anemia Patients: A Randomized Controlled Pilot Trial

Objective. To explore the clinical efficacy and mechanism of compound Shenlu granule (SLG) treatment in patients with aplastic anemia (AA). Methods. A total of 89 AA patients were randomly divided into an SLG supportive group (group A, n = 44) and a control group (group B, n = 45) while continuing W...

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Published in:Evidence-based complementary and alternative medicine 2021, Vol.2021, p.6655848-8
Main Authors: Feng, Zhou, Hu, Xiaoying, Qu, Weiying, Zhu, Xiaoqin, Lu, Jiaying, Huang, Zhongdi, Zhao, Lin, Chen, Pei
Format: Article
Language:English
Subjects:
Anemia
Aplastic anemia
Blood
Chinese medicine
Discriminant analysis
Disease control
Erythrocytes
Hematology
Hemoglobin
Hospitals
Liquid chromatography
Mass spectroscopy
Metabolism
Metabolomics
Patients
Principal components analysis
Quality of life
Remission (Medicine)
Software
Traditional Chinese medicine
tRNA
Variables
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Summary:Objective. To explore the clinical efficacy and mechanism of compound Shenlu granule (SLG) treatment in patients with aplastic anemia (AA). Methods. A total of 89 AA patients were randomly divided into an SLG supportive group (group A, n = 44) and a control group (group B, n = 45) while continuing Western medical management. After 6 months, hemograms, traditional Chinese medicine (TCM) syndrome scores, and overall clinical efficacy rate were assessed. Serum metabolomics characteristics were observed using ultraperformance liquid chromatography-mass spectrometry after SLG intervention. Results. The levels of red blood cell (RBC), hemoglobin (Hb), and platelet (PLT) were increased in both groups after treatment for 6 months (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/6655848