Calcium carbonate nano- and microparticles: synthesis methods and biological applications

Calcium carbonate micro- and nanoparticles are considered as chemically inert materials. Therefore, they are widely considered in the field of biosensing, drug delivery, and as filler material in plastic, paper, paint, sealant, and adhesive industries. The unusual properties of calcium carbonate-bas...

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Bibliographic Details
Published in:3 Biotech 2021-11, Vol.11 (11), p.457, Article 457
Main Authors: Fadia, Preksha, Tyagi, Simona, Bhagat, Stuti, Nair, Abhishek, Panchal, Pooja, Dave, Harsh, Dang, Sadev, Singh, Sanjay
Format: Article
Language:English
Subjects:
Agriculture
Antiinfectives and antibacterials
Antimicrobial activity
Biocompatibility
Bioinformatics
Biomaterials
Biomedical engineering
Biomedical materials
Biosensors
Biotechnology
Calcium carbonate
Cancer Research
Carbonation
Chemistry
Chemistry and Materials Science
Drug delivery
Emulsion polymerization
Microparticles
Morphology
Nanomaterials
Nanoparticles
Nanotechnology
Polymers
Review
Review Article
Stem Cells
Synthesis
Tissue engineering
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Summary:Calcium carbonate micro- and nanoparticles are considered as chemically inert materials. Therefore, they are widely considered in the field of biosensing, drug delivery, and as filler material in plastic, paper, paint, sealant, and adhesive industries. The unusual properties of calcium carbonate-based nanomaterials, such as biocompatibility, high surface-to-volume ratio, robust nature, easy synthesis, and surface functionalization, and ability to exist in a variety of morphologies and polymorphs, make them an ideal candidate for both industrial and biomedical applications. Significant research efforts have been devoted for developing novel synthesis methods of calcium carbonate particles in micrometer and nanometer dimensions. This review highlights different approaches of the synthesis of calcium carbonate micro- and nanoparticles, such as precipitation, slow carbonation, emulsion, polymer-mediated method, including in-situ polymerization, mechano-chemical, microwave-assisted method, and biological methods. The applications of these versatile calcium carbonate micro- and nanoparticles in the biomedical field (such as in drug delivery, therapeutics, tissue engineering, antimicrobial activity, biosensing applications), in industries, and environmental sector has also been comprehensively covered.
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-021-02995-2