Epilepsy and Neurodevelopmental Outcomes in a Cohort of West Syndrome Beyond Two Years of Age

Objective To determine epilepsy and neurodevelopmental outcomes beyond 2 y of age and their putative prognostic factors in children with West syndrome (WS). Methods This cross-sectional study was initiated after approval from Institutional Ethics Committee. A follow-up cohort of 114 children (aged ≥...

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Bibliographic Details
Published in:Indian journal of pediatrics 2022-08, Vol.89 (8), p.765-770
Main Authors: Aramanadka, Reshma, Sahu, Jitendra Kumar, Madaan, Priyanka, Sankhyan, Naveen, Malhi, Prahbhjot, Singhi, Pratibha
Format: Article
Language:English
Subjects:
Gynecology
Medicine
Medicine & Public Health
Original
Original Article
Pediatrics
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Summary:Objective To determine epilepsy and neurodevelopmental outcomes beyond 2 y of age and their putative prognostic factors in children with West syndrome (WS). Methods This cross-sectional study was initiated after approval from Institutional Ethics Committee. A follow-up cohort of 114 children (aged ≥ 2 y) diagnosed and treated for WS at the authors' center were assessed in-person for epilepsy and neurodevelopmental outcomes using Vineland Social Maturity Scale - Malin’s adaptation for Indian children. Subsequently, age at onset, lead-time-to-treatment, etiology, and response to any of the standard therapies were analyzed as possible predictors of these outcomes. Results Of 114 children (mean age: 55 ± 32 mo, 91 boys), structural etiology was the predominant underlying etiology (79.8%) for WS. At 2 y of age, 64% had ongoing seizures. At the last follow-up, 76% had social quotient 
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-021-03918-y