Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes

Given that factors affecting renal function remain unknown, this study aimed to identify key predictors of estimated glomerular filtration rate (eGFR) deterioration, which is a representative of renal function decline in older adults with type 2 diabetes (T2DM). In an exploratory prospective observa...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-10, Vol.100 (40), p.e27420-e27420
Main Authors: Shibata, Yusuke, Yamazaki, Masanori, Kitahara, Junichiro, Okubo, Yosuke, Oiwa, Ako, Sato, Ai, Komatsu, Mitsuhisa
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Diabetes Mellitus, Type 2 - complications
Diabetic Nephropathies - blood
Diabetic Nephropathies - etiology
Disease Progression
Female
Glomerular Filtration Rate
Humans
Male
Observational Study
Prospective Studies
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - etiology
Risk Factors
Uric Acid - blood
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Summary:Given that factors affecting renal function remain unknown, this study aimed to identify key predictors of estimated glomerular filtration rate (eGFR) deterioration, which is a representative of renal function decline in older adults with type 2 diabetes (T2DM). In an exploratory prospective observational study, we enrolled 268 Japanese people with T2DM aged ≥20 years who were followed up at Shinshu University Hospital. Among those, 112 eligible individuals aged ≥65 years were included in the present study. Factors associated with 3-year changes in eGFR (ΔeGFR) and eGFR deterioration (ΔeGFR 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000027420