Analysis of serum hepatitis B virus RNA levels among HBsAg and HBsAb copositive patients and its correlation with HBV DNA

There are approximately 2 billion HBV-infected individuals worldwide, and approximately 1.87% to 7% of these individuals are copositive for HBsAg and HBsAb.Our study detected hepatitis B virus pgRNA (HBV RNA) levels in HBsAg and HBsAb copositive patients and then analyzed the correlation with HBV DN...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-10, Vol.100 (40), p.e27433-e27433
Main Authors: Xiang, Yu, Yang, Yang, Chen, Pu, Lai, Xiaofei, Shi, Shan, Li, Shuang, You, Wenxian
Format: Article
Language:English
Subjects:
Adult
Disease Progression
DNA, Viral - blood
Female
Genotype
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
Hepatitis B virus - genetics
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - virology
Humans
Male
Middle Aged
Observational Study
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Summary:There are approximately 2 billion HBV-infected individuals worldwide, and approximately 1.87% to 7% of these individuals are copositive for HBsAg and HBsAb.Our study detected hepatitis B virus pgRNA (HBV RNA) levels in HBsAg and HBsAb copositive patients and then analyzed the correlation with HBV DNA, HBsAg, ALT, and AST levels. A total of 149 HBsAg and HBsAb copositive patients were identified from 66,617 outpatients.HBV RNA, HBV DNA, HBsAg, ALT, and AST serum levels were significantly different in different natural phases of HBV infection (immune tolerance phase, immune clearance phase, low replication phase, and reactivation phase) with statistical significance (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000027433