Effects of ShenLing BaiZhu San Supplementation on Gut Microbiota and Oxidative Stress in Rats with Ulcerative Colitis

The aim of this study was to evaluate the effect of gut microbiota and antioxidation of Shenling Baizhu San (SLBZS) as a supplement in a rat model of ulcerative colitis (UC) induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Acute intestinal inflammation was induced in 40 male SD rats aged 4 week...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2021-10, Vol.2021, p.1-8
Main Authors: Gu, Daxing, Zhou, Shanshan, Yao, Lili, Tan, Ying, Chi, Xingzi, Shi, Dayou, Guo, Shining, Liu, Cui
Format: Article
Language:English
Subjects:
Abundance
Antioxidants
Chinese medicine
Colon
Digestive system
Drug dosages
Gastrointestinal tract
Inflammatory bowel disease
Intestinal microflora
Metabolism
Metabolites
Microbiomes
Microbiota
Next-generation sequencing
Opportunist infection
Oxidative stress
Physiology
Principal components analysis
Relative abundance
rRNA 16S
Software
Supplements
Ulcerative colitis
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Summary:The aim of this study was to evaluate the effect of gut microbiota and antioxidation of Shenling Baizhu San (SLBZS) as a supplement in a rat model of ulcerative colitis (UC) induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Acute intestinal inflammation was induced in 40 male SD rats aged 4 weeks with 100 mg/kg TNBS, and then three dosages of SLBZS (0.5 g/kg, 1 g/kg, and 1.5 g/kg) were administered for eight days, respectively. Faecal microbiome composition was assessed by 16S rRNA high-throughput sequencing. The result indicated that SLBZS could reduce the diversity of gut microbiota and increased its abundance. At the genus level, the relative abundance of SCFAs producing bacteria including Prevotella and Oscillospira increased, while the relative abundance of opportunistic pathogens including Desulfovibrio and Bilophila decreased. Meanwhile, SLBZS could improve the lesions of colon and significantly reduce the level of MPO, increase the levels of SOD and CAT in rats’ serum. These findings revealed that SLBZS was effective and possessed anticolitic activities in a rat model of UC by reducing macroscopical and microscopical colon injury, enhancing antioxidant capacity, and regulating gut microbiota.
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/3960989