The Inverse Relationship Between Endothelium-Dependent Vasodilation and Blood Pressure is Lost After Cardiopulmonary Bypass

Cardiopulmonary bypass (CPB) is required for the surgical correction of congenital heart defects and incites an acute inflammatory response that impairs endothelial function post-operatively. Therefore, we hypothesized that the pre-operative relationship between endothelial function and blood pressu...

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Bibliographic Details
Published in:Journal of cardiovascular translational research 2021-12, Vol.14 (6), p.1114-1116
Main Authors: Stark, Ryan J., Krispinsky, Luke T., Lamb, Fred S.
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Biomedical Engineering and Bioengineering
Biomedicine
Blood Pressure - drug effects
Cardiology
Cardiopulmonary Bypass
Endothelium, Vascular - physiopathology
Female
Heart Defects, Congenital - surgery
Human Genetics
Humans
Infant
Iontophoresis
Laser-Doppler Flowmetry
Male
Medicine
Medicine & Public Health
Nitroprusside - pharmacology
Short Communication
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Summary:Cardiopulmonary bypass (CPB) is required for the surgical correction of congenital heart defects and incites an acute inflammatory response that impairs endothelial function post-operatively. Therefore, we hypothesized that the pre-operative relationship between endothelial function and blood pressure would be impaired after CPB-mediated inflammation. Using laser Doppler perfusion monitoring coupled with iontophoresis, we found that while there was a significant inverse correlation between endothelium-dependent vascular reactivity to acetylcholine (ACh) stimulation and systolic blood pressure (SBP), this relationship was lost after CPB. No relationship was observed between endothelium-independent vascular reactivity using sodium nitroprusside (SNP) and SBP either pre-CPB or any point thereafter. Additionally, neither CPB time nor inflammatory cytokines correlated with the degree of responsiveness to ACh. These data suggest that the measurement of endothelium impairment after CPB may be more reflective of cardiovascular health than SBP alone.
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-021-10124-w