MicroRNA‑23b‑3p targets non‑SMC condensing I complex subunit G to promote proliferation and inhibit apoptosis of colorectal cancer cells via regulation of the PI3K/AKT signaling pathway

Colorectal cancer (CRC) is one of the most common types of malignancy worldwide and has a poor prognosis. Non-SMC condensing I complex subunit G (NCAPG) has been reported to be upregulated in numerous types of malignant tumor. However, to the best of our knowledge, its clinicopathological and biolog...

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Bibliographic Details
Published in:Oncology letters 2021-12, Vol.22 (6), p.1, Article 812
Main Authors: Li, Peidong, Wen, Jing, Ren, Xiru, Zhou, Yu, Xue, Yuan, Yan, Zaihua, Li, Shengjie, Tian, Hongpeng, Tang, Xue-Gui, Zhang, Guang-Jun
Format: Article
Language:English
Subjects:
Apoptosis
Colorectal cancer
Ethylenediaminetetraacetic acid
Metastasis
MicroRNA
MicroRNAs
Oncology
Patients
Plasmids
Proteins
Reagents
Scientific equipment and supplies industry
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Summary:Colorectal cancer (CRC) is one of the most common types of malignancy worldwide and has a poor prognosis. Non-SMC condensing I complex subunit G (NCAPG) has been reported to be upregulated in numerous types of malignant tumor. However, to the best of our knowledge, its clinicopathological and biological significance in CRC remain to be elucidated. The results of the present study revealed that NCAPG expression levels were upregulated in human CRC tissues and cell lines. The upregulated expression of NCAPG was positively associated with patient clinicopathological characteristics, such as differentiation and tumor size, and independently associated with poor survival. Consistent with the clinical observations, NCAPG was discovered to promote the proliferation and inhibit the apoptosis of CRC cells. Moreover, NCAPG-knockdown inhibited CRC cell proliferation by regulating the PI3K/AKT signaling pathway. Furthermore, NCAPG was identified as a potential target of microRNA (miR)-23b-3p, which was subsequently demonstrated to negatively regulate NCAPG expression. In conclusion, the findings of the current study indicated that the miR-23b-3p/NCAPG/PI3K/AKT signaling axis may play an important role in CRC carcinogenesis, and the status of the molecule may represent a promising prognostic marker for the disease.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2021.13073