Differences in gut microbiota structure in patients with stages 4-5 chronic kidney disease

The gut microbiota can affect human metabolism, immunity, and other biologic pathways through the complex gut-kidney axis (GKA), and in turn participate in the occurrence and development of kidney disease. In this study, 39 patients with stage 4-5 chronic kidney disease (CKD) and 40 healthy individu...

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Published in:American journal of translational research 2021-01, Vol.13 (9), p.10056-10074
Main Authors: Wu, Rong, Ruan, Xing-Lin, Ruan, Dan-Dan, Zhang, Jian-Hui, Wang, Han-Lu, Zeng, Quan-Zuan, Lu, Tao, Gan, Yu-Mian, Luo, Jie-Wei, Wu, Jia-Bin
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Language:English
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Summary:The gut microbiota can affect human metabolism, immunity, and other biologic pathways through the complex gut-kidney axis (GKA), and in turn participate in the occurrence and development of kidney disease. In this study, 39 patients with stage 4-5 chronic kidney disease (CKD) and 40 healthy individuals were recruited and 16S rDNA sequencing was performed to analyze the V3-V4 conserved regions of their microbiota. A total of 795 operational taxonomic units (OTUs) shared between groups or specific to each group were obtained, among which 255 OTUs with significant differences between the two groups were identified ( P
ISSN:1943-8141
1943-8141