Differences in gut microbiota structure in patients with stages 4-5 chronic kidney disease

The gut microbiota can affect human metabolism, immunity, and other biologic pathways through the complex gut-kidney axis (GKA), and in turn participate in the occurrence and development of kidney disease. In this study, 39 patients with stage 4-5 chronic kidney disease (CKD) and 40 healthy individu...

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Published in:American journal of translational research 2021-01, Vol.13 (9), p.10056-10074
Main Authors: Wu, Rong, Ruan, Xing-Lin, Ruan, Dan-Dan, Zhang, Jian-Hui, Wang, Han-Lu, Zeng, Quan-Zuan, Lu, Tao, Gan, Yu-Mian, Luo, Jie-Wei, Wu, Jia-Bin
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container_issue 9
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container_title American journal of translational research
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creator Wu, Rong
Ruan, Xing-Lin
Ruan, Dan-Dan
Zhang, Jian-Hui
Wang, Han-Lu
Zeng, Quan-Zuan
Lu, Tao
Gan, Yu-Mian
Luo, Jie-Wei
Wu, Jia-Bin
description The gut microbiota can affect human metabolism, immunity, and other biologic pathways through the complex gut-kidney axis (GKA), and in turn participate in the occurrence and development of kidney disease. In this study, 39 patients with stage 4-5 chronic kidney disease (CKD) and 40 healthy individuals were recruited and 16S rDNA sequencing was performed to analyze the V3-V4 conserved regions of their microbiota. A total of 795 operational taxonomic units (OTUs) shared between groups or specific to each group were obtained, among which 255 OTUs with significant differences between the two groups were identified ( P
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The differential bacterial genera with the greatest contribution were, in descending order: c_Bacteroidia, o_Bacteroidales, p_Bacteroidetes, c_Clostridia, o_Clostridiales, etc. Those with the greatest contribution in stages 4-5 CKD were, in descending order: p_Proteobacteria, f_Enterobacteriaceae, o_Enterobacteriales, c_Gammaproteobacteria, c_Bacilli, etc. The results suggest that the diversity of the microbiota may affect the occurrence, development, and outcome of the terminal stages of CKD.</description><identifier>ISSN: 1943-8141</identifier><identifier>EISSN: 1943-8141</identifier><identifier>PMID: 34650681</identifier><language>eng</language><publisher>e-Century Publishing Corporation</publisher><subject>Original</subject><ispartof>American journal of translational research, 2021-01, Vol.13 (9), p.10056-10074</ispartof><rights>AJTR Copyright © 2021 2021</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507064/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507064/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids></links><search><creatorcontrib>Wu, Rong</creatorcontrib><creatorcontrib>Ruan, Xing-Lin</creatorcontrib><creatorcontrib>Ruan, Dan-Dan</creatorcontrib><creatorcontrib>Zhang, Jian-Hui</creatorcontrib><creatorcontrib>Wang, Han-Lu</creatorcontrib><creatorcontrib>Zeng, Quan-Zuan</creatorcontrib><creatorcontrib>Lu, Tao</creatorcontrib><creatorcontrib>Gan, Yu-Mian</creatorcontrib><creatorcontrib>Luo, Jie-Wei</creatorcontrib><creatorcontrib>Wu, Jia-Bin</creatorcontrib><title>Differences in gut microbiota structure in patients with stages 4-5 chronic kidney disease</title><title>American journal of translational research</title><description>The gut microbiota can affect human metabolism, immunity, and other biologic pathways through the complex gut-kidney axis (GKA), and in turn participate in the occurrence and development of kidney disease. 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title Differences in gut microbiota structure in patients with stages 4-5 chronic kidney disease
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