Imaging of Skull Base and Orbital Invasion in Sinonasal Cancer: Correlation with Histopathology

Background: Pretreatment assessment of local extension in sinonasal cancer is essential for prognostic evaluation and surgical planning. The aim of this study was to assess the diagnostic performance of two common imaging techniques (CT and MRI) for the diagnosis of skull base and orbital invasion b...

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Bibliographic Details
Published in:Cancers 2021-10, Vol.13 (19), p.4963
Main Authors: Salfrant, Maxime, Garcia, Gabriel C. T. E., Guichard, Jean-Pierre, Bidault, François, Reizine, Daniel, Aupérin, Anne, Bresson, Damien, Verillaud, Benjamin, Herman, Philippe, Moya-Plana, Antoine
Format: Article
Language:English
Subjects:
Adenocarcinoma
Cancer
Cancer therapies
Computed tomography
Contact angle
Diagnosis
Endoscopy
Head & neck cancer
Humanities and Social Sciences
Life Sciences
Magnetic resonance imaging
Medical imaging
Medical prognosis
Methodology
Methods and statistics
Other Statistics
Patients
Radiation therapy
Sinuses
Skull
Statistics
Surgery
Tumors
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Summary:Background: Pretreatment assessment of local extension in sinonasal cancer is essential for prognostic evaluation and surgical planning. The aim of this study was to assess the diagnostic performance of two common imaging techniques (CT and MRI) for the diagnosis of skull base and orbital invasion by comparing imaging findings to histopathological data. Methods: This was a retrospective two-center study including patients with sinonasal cancer involving the skull base and/or the orbit operated on between 2000 and 2019. Patients were included only if pre-operative CT and/or MRI, operative and histopathologic reports were available. A double prospective blinded imaging review was conducted according to predefined radiological parameters. Radiologic tumor extension was compared to histopathological reports, which were considered the gold standard. The predictive positive value (PPV) for the diagnosis of skull base/orbital invasion was calculated for each parameter. Results: A total of 176 patients were included. Ethmoidal intestinal-type adenocarcinoma was the most common type of cancer (41%). The PPV for major modification of the bony skull base was 78% on the CT scan, and 89% on MRI. MRI signs of dural invasion with the highest PPVs were: contact angle over 45° between tumor and dura (86%), irregular deformation of dura adjacent to tumor (87%) and nodular dural enhancement over 2 mm in thickness (87%). Signs of orbital invasion had low PPVs (
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13194963