Effects of Fluoride and Calcium Phosphate-Based Varnishes in Children at High Risk of Tooth Decay: A Randomized Clinical Trial

Background: The aim of this study was to investigate the effect of the application of two varnishes—MI Varnish (5% sodium fluoride with CPP-ACP) and Clinpro White Varnish (5% sodium fluoride with fTCP)—applied every three months in children with high caries risk for 12 months on plaque indexes, sali...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-09, Vol.18 (19), p.10049
Main Authors: Poza-Pascual, Andrea, Serna-Muñoz, Clara, Pérez-Silva, Amparo, Martínez-Beneyto, Yolanda, Cabello, Inmaculada, Ortiz-Ruiz, Antonio José
Format: Article
Language:English
Subjects:
Acids
Biofilms
Calcium fluoride
Calcium isotopes
Calcium phosphates
Chemical elements
Children
Clinical trials
Dental caries
Disease prevention
Enamel
Fluorides
Hygiene
Iron 57
Lactic acid
Lead isotopes
Patients
Placebos
Proteins
Risk
Saliva
Sodium
Sodium fluoride
Teeth
Toothpaste
Varnishes
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Summary:Background: The aim of this study was to investigate the effect of the application of two varnishes—MI Varnish (5% sodium fluoride with CPP-ACP) and Clinpro White Varnish (5% sodium fluoride with fTCP)—applied every three months in children with high caries risk for 12 months on plaque indexes, salivary pH, salivary lactic acid and chemical elements concentrations. Methods: We included 58 children aged 4–12 years, assigned to control (placebo), Clinpro and MI groups. Baseline and three-month saliva samples were taken. We assessed changes in pH, lactic acid concentrations and chemical elements in saliva. Results: At 12 months, all groups showed a nonsignificant increase in pH levels and a reduction in lactic acid, which was greatest in the placebo group. There was a significant reduction in 24Mg (p =
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph181910049