Nucleic Acid Drugs—Current Status, Issues, and Expectations for Exosomes

Nucleic acid drugs are being developed as novel therapeutic modalities. They have great potential to treat human diseases such as cancers, viral infections, and genetic disorders due to unique characteristics that make it possible to approach undruggable targets using classical small molecule or pro...

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Bibliographic Details
Published in:Cancers 2021-10, Vol.13 (19), p.5002
Main Author: Yamada, Yoji
Format: Article
Language:English
Subjects:
Acids
Antibodies
Antitumor agents
Cancer therapies
Coronaviruses
COVID-19
Disease
Drug development
Drug therapy
Drugs
Exosomes
FDA approval
Gene therapy
Genetic disorders
Genomes
MicroRNAs
Mutation
Nanoparticles
Nucleic acids
Pandemics
Proteins
Review
Severe acute respiratory syndrome coronavirus 2
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Summary:Nucleic acid drugs are being developed as novel therapeutic modalities. They have great potential to treat human diseases such as cancers, viral infections, and genetic disorders due to unique characteristics that make it possible to approach undruggable targets using classical small molecule or protein/antibody-based biologics. In this review, I describe the advantages, classification, and clinical status of nucleic acid therapeutics. To date, more than 10 products have been launched, and many products have been tested in clinics. To promote the use of nucleic acid therapeutics such as antibodies, several hurdles need to be surmounted. The most important issue is the delivery of nucleic acids and several other challenges have been reported. Recent advanced delivery platforms are lipid nanoparticles and ligand conjugation approaches. With the progress of exosome biology, exosomes are expected to contribute to the solution of various problems associated with nucleic acid drugs.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13195002