Long-Term Outcome in Systemic Lupus Erythematosus; Knowledge from Population-Based Cohorts

Background: Accurate knowledge of outcomes in Systemic Lupus Erythematosus (SLE) is crucial to understanding the true burden of the disease. The main objective of this systematic review was to gather all population-based studies on mortality, end-stage renal disease (ESRD) and cancer in SLE. Method:...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-09, Vol.10 (19), p.4306
Main Authors: Reppe Moe, Sigrid, Haukeland, Hilde, Molberg, Øyvind, Lerang, Karoline
Format: Article
Language:English
Subjects:
Boolean
Cancer
Clinical medicine
Epidemiology
Hospitals
Infections
Kidney diseases
Lupus
Minority & ethnic groups
Mortality
Patients
Population-based studies
Review
Survival analysis
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Summary:Background: Accurate knowledge of outcomes in Systemic Lupus Erythematosus (SLE) is crucial to understanding the true burden of the disease. The main objective of this systematic review was to gather all population-based studies on mortality, end-stage renal disease (ESRD) and cancer in SLE. Method: We performed a systematic literature search in two electronic databases (MEDLINE and Embase) to identify all population-based articles on SLE and survival, mortality, ESRD and cancer. The SLE diagnosis had to be verified. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). Results: We included 40/1041 articles on mortality (27), ESRD (11) and cancer (3), of which six were defined as inception studies. In the total SLE cohort, the standardized mortality ratio ranged from 1.9 to 4.6. Cardiovascular disease was the most frequent cause of death in studies with follow-up times over 15 years. SLE progressed to ESRD in 5–11% of all SLE patients. There are no data supporting increased cancer incidence from population-based inception cohorts. Conclusion: There is a need for more population-based studies on outcomes of SLE, especially inception studies, with the use of control groups and follow-up times over 15 years.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10194306