FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19

Background: Liver involvement in Coronavirus disease 2019 (COVID-19) has been recognised. We aimed to investigate the correlation of non-invasive surrogates of liver steatosis, fibrosis and inflammation using transient elastography (TE) and FibroScan-AST (FAST) score with (a) clinical severity and (...

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Published in:Journal of clinical medicine 2021-09, Vol.10 (19), p.4355
Main Authors: Zelenika, Marko, Lucijanic, Marko, Bokun, Tomislav, Bozin, Tonci, Barisic Jaman, Mislav, Tjesic Drinkovic, Ida, Pastrovic, Frane, Madir, Anita, Luksic, Ivica, Piskac Zivkovic, Nevenka, Luetic, Kresimir, Krznaric, Zeljko, Ostojic, Rajko, Filipec Kanizaj, Tajana, Bogadi, Ivan, Virovic Jukic, Lucija, Kukla, Michal, Grgurevic, Ivica
Format: Article
Language:English
Subjects:
Age
Biochemistry
Blood platelets
Chronic illnesses
Clinical medicine
Comorbidity
Coronaviruses
COVID-19
Diabetes
Hospitalization
Hypertension
Liver diseases
Metabolism
Mortality
Pandemics
Patients
Severe acute respiratory syndrome coronavirus 2
Software
Ventilators
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Summary:Background: Liver involvement in Coronavirus disease 2019 (COVID-19) has been recognised. We aimed to investigate the correlation of non-invasive surrogates of liver steatosis, fibrosis and inflammation using transient elastography (TE) and FibroScan-AST (FAST) score with (a) clinical severity and (b) 30-day composite outcome of mechanical ventilation (MV) or death among patients hospitalized due to COVID-19. Method: Patients with non-critical COVID-19 at admission were included. Liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) were assessed by TE. Clinical severity of COVID-19 was assessed by 4C Mortality Score (4CMS) and need for high-flow nasal cannula (HFNC) oxygen supplementation. Results: 217 patients were included (66.5% males, median age 65 years, 4.6% with history of chronic liver disease). Twenty-four (11.1%) patients met the 30-day composite outcome. Median LSM, CAP and FAST score were 5.2 kPa, 274 dB/m and 0.31, respectively, and neither was associated with clinical severity of COVID-19 at admission. In multivariate analysis FAST > 0.36 (OR 3.19, p = 0.036), 4CMS (OR 1.68, p = 0.002) and HFNC (OR 7.03, p = 0.001) were independent predictors of adverse composite outcome. Conclusion: Whereas LSM and CAP failed to show correlation with COVID-19 severity and outcomes, FAST score was an independent risk factor for 30-day mortality or need for MV.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10194355