Total Lesion Glycolysis Improves Tumor Burden Evaluation and Risk Assessment at Diagnosis in Hodgkin Lymphoma

Hodgkin lymphoma (HL) is a hematological malignancy with an excellent prognosis. However, we still need to identify those patients that could experience failed standard frontline chemotherapy. Tumor burden evaluation and standard decisions are based on Ann Arbor (AA) staging, but this approach may b...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-09, Vol.10 (19), p.4396
Main Authors: Herraez, Ines, Bento, Leyre, Daumal, Jaume, Repetto, Alessandra, Del Campo, Raquel, Perez, Sandra, Ramos, Rafael, Ibarra, Javier, Mestre, Francesc, Bargay, Joan, Lopez, Paloma, Garcias-Ladaria, Joan, Sampol, Antonia, Gutierrez, Antonio
Format: Article
Language:English
Subjects:
Bone marrow
Clinical medicine
Drug dosages
Lymphoma
Medical prognosis
Metabolism
Nuclear medicine
Patients
Radiation therapy
Response rates
Risk assessment
Risk factors
Survival analysis
Tomography
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Summary:Hodgkin lymphoma (HL) is a hematological malignancy with an excellent prognosis. However, we still need to identify those patients that could experience failed standard frontline chemotherapy. Tumor burden evaluation and standard decisions are based on Ann Arbor (AA) staging, but this approach may be insufficient in predicting outcomes. We aim to study new ways to assess tumor burden through volume-based PET parameters to improve the risk assessment of HL patients. We retrospectively analyzed 101 patients with HL from two hospitals in the Balearic Islands between 2011 and 2018. Higher metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were significantly associated with a higher incidence of III-IV AA stages, B-symptoms, hypoalbuminemia, lymphopenia, and higher IPS. Standardized uptake value (SUVmax) was significantly related to AA stage and hypoalbuminemia. We found that TLG or the combination of SUVmax, TLG, and MTV significantly improved the risk assessment when compared to AA staging. We conclude that TLG is the best single PET/CT-related tumor-load parameter that significantly improves HL risk assessment when compared to AA staging. If confirmed in a larger and validated sample, this information could be used to modify standard frontline therapy and justifies the inclusion of TLG inside an HL prognostic score.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10194396