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Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli
Although aminoglycosides are one of the common classes of antibiotics that have been widely used for treating infections caused by pathogenic bacteria, the evolution of bacterial resistance mechanisms and their inherent toxicity have diminished their applicability. Biocompatible carrier systems can...
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| Published in: | Polymers 2021-09, Vol.13 (19), p.3326 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c415t-1add852cd8e6063e92c9c06691a3d88eab6ab26ab35a356884d2fc9b92c81fb13 |
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| container_issue | 19 |
| container_start_page | 3326 |
| container_title | Polymers |
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| creator | Tiburcio, Estefanía García-Junceda, Eduardo Garrido, Leoncio Fernández-Mayoralas, Alfonso Revuelta, Julia Bastida, Agatha |
| description | Although aminoglycosides are one of the common classes of antibiotics that have been widely used for treating infections caused by pathogenic bacteria, the evolution of bacterial resistance mechanisms and their inherent toxicity have diminished their applicability. Biocompatible carrier systems can help sustain and control the delivery of antibacterial compounds while reducing the chances of antibacterial resistance or accumulation in unwanted tissues. In this study, novel chitosan gel beads were synthesized by a double ionic co-crosslinking mechanism. Tripolyphosphate and alginate, a polysaccharide obtained from marine brown algae, were employed as ionic cross-linkers to prepare the chitosan-based networks of gel beads. The in vitro release of streptomycin and kanamycin A was bimodal; an initial burst release was observed followed by a diffusion mediated sustained release, based on a Fickian diffusion mechanism. Finally, in terms of antibacterial properties, the particles resulted in growth inhibition of Gram-negative (
) bacteria. |
| doi_str_mv | 10.3390/polym13193326 |
| format | article |
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) bacteria.</description><subject>Acids</subject><subject>Alginates</subject><subject>Aminoglycosides</subject><subject>Antibacterial materials</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Beads</subject><subject>Bioaccumulation</subject><subject>Biocompatibility</subject><subject>Chitosan</subject><subject>Crosslinking</subject><subject>Drug delivery systems</subject><subject>Drug resistance</subject><subject>E coli</subject><subject>Infections</subject><subject>Microspheres</subject><subject>Polymers</subject><subject>Polysaccharides</subject><subject>Scanning electron microscopy</subject><subject>Spectrum analysis</subject><subject>Streptomycin</subject><subject>Sustained release</subject><subject>Toxicity</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpVkd1LIzEUxYMoKurjvi4D-zw2H5M0eVkoRVehog_uc7iTZNrINJlNpkL96zdDVTQQcnPz49wTDkI_CL5mTOHZEPv9ljCiGKPiCJ1TPGd1wwQ-_lKfoaucX3BZDReCzE_RGWtEQ0hDz9H-KbkBEow-hgqCrZabcjOjS_7t0Ixdtdj6ENf93sTsratXEaybSD_GDGH2nPxkZNjEPGxgdLNFv_ahFNWDN2lquuRyBWvwIY_VzXVlYu8v0UkHfXZX7-cF-nt787y8q1ePf-6Xi1VtGsLHmoC1klNjpRNYMKeoUQYLoQgwK6WDVkBLy2YcGBdSNpZ2RrWFk6RrCbtAvw-6w67dOmtcGBP0ekh-C2mvI3j9_SX4jV7HVy05oUSpIvDrXSDFfzuXR_0SdykUz5pyiZXkcs4LVR-o6cc5ue5zAsF6Ckt_C6vwP7_a-qQ_omH_AY0VlE0</recordid><startdate>20210928</startdate><enddate>20210928</enddate><creator>Tiburcio, Estefanía</creator><creator>García-Junceda, Eduardo</creator><creator>Garrido, Leoncio</creator><creator>Fernández-Mayoralas, Alfonso</creator><creator>Revuelta, Julia</creator><creator>Bastida, Agatha</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2344-8743</orcidid><orcidid>https://orcid.org/0000-0001-6225-7336</orcidid><orcidid>https://orcid.org/0000-0002-1241-7538</orcidid><orcidid>https://orcid.org/0000-0001-5364-6532</orcidid><orcidid>https://orcid.org/0000-0002-5141-9595</orcidid></search><sort><creationdate>20210928</creationdate><title>Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli</title><author>Tiburcio, Estefanía ; 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| ispartof | Polymers, 2021-09, Vol.13 (19), p.3326 |
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| language | eng |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Acids Alginates Aminoglycosides Antibacterial materials Antibiotics Bacteria Bacterial infections Beads Bioaccumulation Biocompatibility Chitosan Crosslinking Drug delivery systems Drug resistance E coli Infections Microspheres Polymers Polysaccharides Scanning electron microscopy Spectrum analysis Streptomycin Sustained release Toxicity |
| title | Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli |
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