Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia

Abstract Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's...

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Bibliographic Details
Published in:Leukemia research 2010-12, Vol.34 (12), p.1674-1676
Main Authors: Tirado, Carlos A, Chen, Weina, Huang, Lily Jun-shen, Laborde, Carrie, Hiemenz, Matthew C, Valdez, Federico, Ho, Kevin, Winick, Naomi, Lou, Zhenjun, Koduru, Prasad
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
B-lymphoblastic leukemia
Children
Chromosomes, Human, Pair 22 - genetics
Chromosomes, Human, Pair 9 - genetics
Hematology, Oncology and Palliative Medicine
Humans
JAK2 rearrangement
Janus Kinase 2 - genetics
Leukemia, B-Cell - drug therapy
Leukemia, B-Cell - genetics
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
t(9
22)(p24
q11.2)
Translocation, Genetic
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Summary:Abstract Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2010.05.031