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Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia
Abstract Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's...
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| Published in: | Leukemia research 2010-12, Vol.34 (12), p.1674-1676 |
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| container_end_page | 1676 |
| container_issue | 12 |
| container_start_page | 1674 |
| container_title | Leukemia research |
| container_volume | 34 |
| creator | Tirado, Carlos A Chen, Weina Huang, Lily Jun-shen Laborde, Carrie Hiemenz, Matthew C Valdez, Federico Ho, Kevin Winick, Naomi Lou, Zhenjun Koduru, Prasad |
| description | Abstract Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed. |
| doi_str_mv | 10.1016/j.leukres.2010.05.031 |
| format | article |
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We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2010.05.031</identifier><identifier>PMID: 20594592</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; B-lymphoblastic leukemia ; Children ; Chromosomes, Human, Pair 22 - genetics ; Chromosomes, Human, Pair 9 - genetics ; Hematology, Oncology and Palliative Medicine ; Humans ; JAK2 rearrangement ; Janus Kinase 2 - genetics ; Leukemia, B-Cell - drug therapy ; Leukemia, B-Cell - genetics ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; t(9 ;22)(p24 ;q11.2) ; Translocation, Genetic</subject><ispartof>Leukemia research, 2010-12, Vol.34 (12), p.1674-1676</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-f2ce1eb66797db232e4e98fa8c005cda0040caea4eeba238b666c18b2bbccf713</citedby><cites>FETCH-LOGICAL-c553t-f2ce1eb66797db232e4e98fa8c005cda0040caea4eeba238b666c18b2bbccf713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20594592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tirado, Carlos A</creatorcontrib><creatorcontrib>Chen, Weina</creatorcontrib><creatorcontrib>Huang, Lily Jun-shen</creatorcontrib><creatorcontrib>Laborde, Carrie</creatorcontrib><creatorcontrib>Hiemenz, Matthew C</creatorcontrib><creatorcontrib>Valdez, Federico</creatorcontrib><creatorcontrib>Ho, Kevin</creatorcontrib><creatorcontrib>Winick, Naomi</creatorcontrib><creatorcontrib>Lou, Zhenjun</creatorcontrib><creatorcontrib>Koduru, Prasad</creatorcontrib><title>Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Abstract Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. 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The molecular genetic and clinicopathologic features of these cases were reviewed.</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>B-lymphoblastic leukemia</subject><subject>Children</subject><subject>Chromosomes, Human, Pair 22 - genetics</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>JAK2 rearrangement</subject><subject>Janus Kinase 2 - genetics</subject><subject>Leukemia, B-Cell - drug therapy</subject><subject>Leukemia, B-Cell - genetics</subject><subject>Male</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>t(9 ;22)(p24 ;q11.2)</subject><subject>Translocation, Genetic</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFUk1v1DAUtBCILoWfAMqN9pBgP8dZR5WKStXyVcEBuGI5zsvWWyfe2slK--9xtEsFXDjZfp43M_Y8Ql4yWjDKqjfrwuF0FzAWQFONioJy9ogsmFzyXEguHpMFZaXIgUF1RJ7FuKaUiprVT8kRpE0paliQn1_8Fl326eIzZAF1CHpYYY_DmE5xcqMdVlkXfJ_pbDypzwBOTzZQnt0zVsBpZofsXa7NNGLmdv3m1jdOx9GabPaGvdXPyZNOu4gvDusx-XF99f3yQ37z9f3Hy4ub3AjBx7wDgwybqlrWy7YBDlhiLTstTbJsWk1pSY1GXSI2GrhMyMow2UDTGNMtGT8m53vezdT02Jr0gKCd2gTb67BTXlv1981gb9XKb5UUrKSSJ4LXB4Lg7yeMo-ptNOicHtBPUcmK8iVIOkuJPdIEH2PA7kGFUTVHo9bqEI2ao1FUqBRN6nv1p8WHrt9ZJMDbPQDTR20tBhWNxcFgawOaUbXe_lfi_B8G4-xgjXZ3uMO49lMYUgqKqQiKqm_zfMzjwdJkQA0l_wX-PLeU</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Tirado, Carlos A</creator><creator>Chen, Weina</creator><creator>Huang, Lily Jun-shen</creator><creator>Laborde, Carrie</creator><creator>Hiemenz, Matthew C</creator><creator>Valdez, Federico</creator><creator>Ho, Kevin</creator><creator>Winick, Naomi</creator><creator>Lou, Zhenjun</creator><creator>Koduru, Prasad</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20101201</creationdate><title>Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia</title><author>Tirado, Carlos A ; 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| source | Elsevier |
| subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols - administration & dosage B-lymphoblastic leukemia Children Chromosomes, Human, Pair 22 - genetics Chromosomes, Human, Pair 9 - genetics Hematology, Oncology and Palliative Medicine Humans JAK2 rearrangement Janus Kinase 2 - genetics Leukemia, B-Cell - drug therapy Leukemia, B-Cell - genetics Male Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics t(9 22)(p24 q11.2) Translocation, Genetic |
| title | Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia |
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