The differential activation of cardiovascular hormones across distinct stages of portal hypertension predicts clinical outcomes

Background and aims The cardiovascular hormones renin/angiotensin/aldosterone (RAA), brain-type natriuretic peptide (BNP)and arginine-vasopressin (AVP) are key regulators of systemic circulatory homeostasis in portal hypertension (PH). We assessed (i) the activation of renin, BNP and AVP across dist...

Full description

Saved in:
Bibliographic Details
Published in:Hepatology international 2021-10, Vol.15 (5), p.1160-1173
Main Authors: Hartl, Lukas, Jachs, Mathias, Desbalmes, Christopher, Schaufler, Dunja, Simbrunner, Benedikt, Paternostro, Rafael, Schwabl, Philipp, Bauer, David Josef Maria, Semmler, Georg, Scheiner, Bernhard, Bucsics, Theresa, Eigenbauer, Ernst, Marculescu, Rodrig, Szekeres, Thomas, Peck-Radosavljevic, Markus, Kastl, Stefan, Trauner, Michael, Mandorfer, Mattias, Reiberger, Thomas
Format: Article
Language:English
Subjects:
Aldosterone
Angiotensin
Argipressin
Biomarkers
Blood pressure
Brain natriuretic peptide
Clinical outcomes
Colorectal Surgery
Confidence intervals
Heart rate
Hepatology
Homeostasis
Hormones
Humans
Hypertension
Hypertension, Portal
Liver Cirrhosis
Liver diseases
Medicine
Medicine & Public Health
Mortality
Original
Original Article
Patients
Plasma levels
Portal Pressure
Renin
Risk analysis
Risk factors
Surgery
Vasopressin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and aims The cardiovascular hormones renin/angiotensin/aldosterone (RAA), brain-type natriuretic peptide (BNP)and arginine-vasopressin (AVP) are key regulators of systemic circulatory homeostasis in portal hypertension (PH). We assessed (i) the activation of renin, BNP and AVP across distinct stages of PH and (ii) whether activation of these hormones correlates with clinical outcomes. Methods Plasma levels of renin, proBNP and copeptin (AVP biomarker) were determined in 663 patients with advanced chronic liver disease (ACLD) undergoing hepatic venous pressure gradient (HVPG) measurement at the Vienna General Hospital between 11/2011 and 02/2019. We stratified for Child stage (A–C), HVPG (6–9 mmHg, 10–15 mmHg, ≥ 16 mmHg) and compensated vs. decompensated ACLD. Results With increasing PH, hyperdynamic state was indicated by higher heart rates (6–9 mmHg: median 71.0 [IQR 18.0] bpm, 10–15 mmHg: 76.0 [19.0] bpm, ≥ 16 mmHg: 80.0 [22.0] bpm; p  
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-021-10203-9